CD21, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | CD21, Human |
| Clone | REA940 |
| Host Species | Recombinant Human |
| Reactive Species | human, other |
| Isotype | IgG1 |
| Format | APC-Vio 770 conjugate |
| Size | 100 tests in 200 µL |
| Concentration | 1:50 |
| Applications | Flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | CD21 Antibody, anti-human, APC-Vio® 770, REAfinity™. Clone REA940 recognizes the human CD21 antigen, a type I membrane glycoprotein. Expression of CD21 in humans is found on B cells, follicular dendritic cells, subsets of epithelial cells, and thymic T cells. The primary function attributed to CD21 has been to amplify the B cell receptor (BCR)-mediated signal transduction in response to antigen recognition. To enhance the BCR mediated activation, CD21 associates with CD19 and CD81 in a B cell-specific signal transduction complex, where interaction of BCR with CR2/CD19 amplifies the signals. In addition, CD21 serves as a receptor for split products of complement protein C3, the gp350/220 viral coat protein of the EBV and the immunoregulatory protein CD23. | Additional information: Clone REA940 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | CR2, C3dR, CR, CVID7, SLEB9 |
| Gene, Accession # | Gene ID: 1380 |
| Catalog # | 130-130-028 |
| Price | $400 |
| Order / More Info | CD21, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Roberts, M. L. et al. (1996) Epstein - Barr virus binding to CD21, the virus receptor, activates resting B cells via an intracellular pathway that is linked to B cell infection. Virology 77: 3077-3085. | Braun, M. et al. (1998) Human B and T lymphocytes have similar amounts of CD21 mRNA, but differ in surface expression of the CD21 glycoprotein. Int. Immunol. 10: 1197-1202. | Cherukuri, A. et al. (2001) The role of the CD19/CD21 complex in B cell processing and presentation of complement-tagged antigens. J Immunol 167: 163-172. | Barrington, R. A. et al. (2005) CD21/CD19 coreceptor signaling promotes B cell survival during primary immune responses. J Immunol 175: 2589-2867. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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