p53 acK382, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | p53 acK382, Human |
| Clone | REA529 |
| Host Species | Recombinant Human |
| Reactive Species | human |
| Isotype | IgG1 |
| Format | allophycocyanin (APC) conjugate |
| Size | 100 tests in 1 mL |
| Concentration | 1:11 |
| Applications | MICS (MACSima Imaging Cyclic Staining), Immunofluorescence, Immunohistochemistry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | p53 acK382 Antibody, anti-human, APC, REAfinity™. Clone REA529 recognizes the human cellular tumor antigen p53 acetylated in the C-terminal region at lysine 382 (acK382). The p53 protein is an important regulator of cell growth and, thus, functions as a tumor suppressor in many tumor types. The p53 tumor suppressor gene is altered or deleted in most solid human tumors. It is tightly regulated and plays a critical role in the cellular response to environmental stress. Upon a cell's exposure to stress, such as hypoxia or genomic damage, the p53 protein is expressed at high levels and is post-translationally modified. These modifications, which include phosphorylation, acetylation, and glycosylation occur rapidly and lead to the activation of p53, resulting in either G1 growth arrest or programmed cell death. The acetylation levels of p53 are significantly enhanced in response to stress and correlate well with p53 activation and stabilization. p53 acetylation at K382 plays an important role in depsipeptide-induced p21(Waf1/Cip1) expression. | Additional information: Clone REA529 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | TP53, BCC7, LFS1, TRP53, NY-CO-13 |
| Gene, Accession # | Gene ID: 7157 |
| Catalog # | 130-109-018 |
| Price | $325 |
| Order / More Info | p53 acK382, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Zakut-Houri, R. et al. (1985) Human p53 cellular tumor antigen: cDNA sequence and expression in COS cells. EMBO J. 4 (5): 1251-1255. | Tang, Y. et al. (2008) Acetylation is indispensable for p53 activation. Cell 133 (4): 612-626. | Zhao, Y. et al. (2006) Acetylation of p53 at lysine 373/382 by the histone deacetylase inhibitor depsipeptide induces expression of p21(Waf1/Cip1). Mol. Cell. Biol. 26 (7): 2782-2790. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
Profile of MILTENYI BIOTEC B.V. & Co. KG