CD68, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | CD68, Human |
| Clone | REAL1346 |
| Host Species | Recombinant Human |
| Reactive Species | human |
| Isotype | n/a |
| Format | phycoerythrin (PE) conjugate |
| Size | 200 µL |
| Concentration | n/a |
| Applications | MICS (MACSima Imaging Cyclic Staining), Immunohistochemistry, Immunofluorescence |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | CD68 Antibody, anti-human, PE, REAdye_lease™. Clone REAL1346 is an antibody fragment derived from the full CD68 antibody molecule. It displays no binding to Fc receptors. The recombinantly engineered antibody fragments are multimerized to form the REAdye_lease Complex to bind markers with high avidity. | Clone REAL1346 recognizes the human CD68 antigen, a 110 kDa type I transmembrane glycoprotein classified as a lysosomal/ endosomal-associated membrane glycoprotein (LAMP) family member. CD68 is highly expressed by human monocytes and tissue macrophages but also found in subpopulations of B cells, fibroblasts, endothelial, and other cells. It is found predominantely in late endosomal and lysosomal compartments, with a modest level of cell surface expression. CD68 is suggested to be involved in phagocytic activities of tissue macrophages, in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. | For removal of REAdye_lease fluorochromes for optional relabeling with different fluorochrome-conjugated REAdye_lease antibodies use the REAlease Support Kit (130-120-675). | |
| Immunogen | n/a |
| Other Names | gp110, Lamp4, SCARD1, macrosialin |
| Gene, Accession # | n/a |
| Catalog # | 130-131-521 |
| Price | $454 |
| Order / More Info | CD68, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Saito, N. et al. (1991) Ultrastructural localization of the CD68 macrophage-associated antigen in human blood neutrophils and monocytes. Am. J. Pathol. 139: 1053-1059. | Kurushima, H. et al. (2000) Surface expression and rapid internalization of macrosialin (mouse CD68) on elicited mouse peritoneal macrophages. J. Leukoc. Biol. 67: 104-108. | Gottfried, L. A. et al. (2008) Expression of CD68 in non-myeloid cell types. Scand. J. Immunol. 67: 453-463. | van Olst, L. et al. (2021) Meningeal inflammation in multiple sclerosis induces phenotypic changes in cortical microglia that differentially associate with neurodegeneration. Acta Neuropathologica 141 (6): 881-899. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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