GARP (LRRC32), Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | GARP (LRRC32), Human |
| Clone | REA166 |
| Host Species | Recombinant Human |
| Reactive Species | human |
| Isotype | IgG1 |
| Format | Vio Bright B515 conjugate |
| Size | 30 tests in 60 µL |
| Concentration | 1:50 |
| Applications | Flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | GARP (LRRC32) Antibody, anti-human, Vio® Bright B515, REAfinity™. Clone REA166 recognizes the human glycoprotein A repetitions predominant (GARP) antigen, a 80 kDa type I membrane glycoprotein which belongs to the family of leucine rich repeat proteins. Expression of GARP protein is found on megakaryocytes, platelets, and activated regulatory T cells (Treg cells). GARP has been found to be associated with latency associated peptide (LAP), the prodomain responsible for conferring latency to non-active TGF-β. Thus, GARP as a latent TGF-β-binding protein (LTBP) regulates the surface expression of TGF-β and serves as a carrier of LAP, at the cell surface, to immune response active sites, where TGF-β is eventually activated and released to exert further physiological functions such as differentiation of regulatory T cells. | Additional information: Clone REA166 displays negligible binding to Fc receptors. | |
| Immunogen | n/a |
| Other Names | LRRC32, D11S833E, Glycoprotein A repetitions predominant (GARP), LRRC32 |
| Gene, Accession # | Gene ID: 2615 |
| Catalog # | 130-120-106 |
| Price | $154 |
| Order / More Info | GARP (LRRC32), Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Zhou, A. X. et al. (2013) GARP-TGF-β complexes negatively regulate regulatory T cell development and maintenance of peripheral CD4+ T cells in vivo. J Immunol 190 (10): 5057-5064. | Tran, D. Q. et al. (2009) GARP (LRRC32) is essential for the surface expression of latent TGF-β on platelets and activated FOXP3+ regulatory T cells. Proc. Natl. Acad. Sci. U.S.A. 106: 13445-13450. | Ollendorff, V. et al. (1994) The GARP gene encodes a new member of the family of leucine-rich repeat-containing proteins. Cell Growth Differ. 5: 213-219. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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