Cyclin E1, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | Cyclin E1, Human |
| Clone | REAL1136 |
| Host Species | Recombinant Human |
| Reactive Species | human |
| Isotype | n/a |
| Format | fluorescein (FITC) conjugate |
| Size | 200 µL |
| Concentration | n/a |
| Applications | MICS (MACSima Imaging Cyclic Staining), Immunohistochemistry, Immunofluorescence |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Cyclin E1 Antibody, anti-human, FITC, REAdye_lease™. Clone REAL1136 is an antibody fragment derived from the full Cyclin E1 antibody molecule. It displays no binding to Fc receptors. The recombinantly engineered antibody fragments are multimerized to form the REAdye_lease Complex to bind markers with high avidity. | Clone REAL1136 recognizes the Cyclin E1, also known as CCNE1, that is a member of the highly conserved cyclin family. Cyclins are regulators of CDKs (Cyclin-dependent kinases). In a protein complex it functions as a regulatory subunit of CDK2, that is essential for the control of the cell cycle at the G1/S (start) transition. Cyclin E1 is present in testis and placenta and weakly expressed on bronchial epithelial cells. Mutations leads to overexpression of this gene and have been observed in many tumors. | For removal of REAdye_lease fluorochromes for optional relabeling with different fluorochrome-conjugated REAdye_lease antibodies use the REAlease Support Kit (130-120-675). | |
| Immunogen | n/a |
| Other Names | CCNE, G1/S-specific cyclin-E1, CCNE1 |
| Gene, Accession # | n/a |
| Catalog # | 130-131-028 |
| Price | $444 |
| Order / More Info | Cyclin E1, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Koff, A. et al. (1992) Formation and activation of a cyclin E-cdk2 complex during the G1 phase of the human cell cycle. Science 257 (5077): 1689-1694. | Ohtsubo, M. et al. (1995) Human cyclin E, a nuclear protein essential for the G1-to-S phase transition. Mol. Cell. Biol. 15 (5): 2612-2624. | Nakayama, K. et al. (2016) CCNE1 amplification is associated with aggressive potential in endometrioid endometrial carcinomas. Int. J. Oncol. 48 (2): 506-516. | Turner, N. C. et al. (2019) Cyclin E1 Expression and Palbociclib Efficacy in Previously Treated Hormone Receptor-Positive Metastatic Breast Cancer. J. Clin. Oncol. 37 (14): 1169-1178. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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