IL-12 (p35/p70), Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | IL-12 (p35/p70), Human |
| Clone | REA121 |
| Host Species | Recombinant Human |
| Reactive Species | human |
| Isotype | IgG1 |
| Format | fluorescein (FITC) conjugate |
| Size | 100 tests in 1 mL |
| Concentration | 1:10 |
| Applications | Intracellular flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | IL-12 (p35/p70) Antibody, anti-human, FITC, REAfinity™. Interleukin-12 (IL-12) is a 70-75 kDa heterodimeric cytokine composed of a 40 kDa heavy chain and a 35 kDa light chain. It is produced mainly by monocytes and macrophages as well as dendritic cells, primarily in response to stimulation with bacterial or viral antigens. IL-12 has also been described to be produced by non-hematopoietic cells such as keratinocytes and epidermoid carcinomas. IL-12 displays various effects on both NK and T cells, playing an essential role in the interaction between innate and adaptive immunity: It induces the production of IFN-γ alone or in synergy with IL-2, is a co-stimulator of both NK and T cell proliferation, and enhances cytolytic activity of both cell types. Moreover, IL-12 promotes the development of T helper 1 (T?1)-specific immune responses by promoting the differentiation of CD4+ cells towards a T?1 phenotype while inhibiting the production of T?2 cells. The antibody clone REA121 reacts with the p35 kDa chain and the p70 kDa heterodimer of human IL-12, but not with IL-12 p40. It recognizes the same epitope as clone B-T21. | Additional information: Clone REA121 displays negligible binding to Fc receptors. | |
| Immunogen | n/a |
| Other Names | IL12A, CLMF, IL-12A, NFSK, NKSF1, P35 |
| Gene, Accession # | Gene ID: 3592 |
| Catalog # | 130-103-674 |
| Price | $264 |
| Order / More Info | IL-12 (p35/p70), Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | D?Andrea, A. et al. (1992) Production of natural killer cell stimulatory factor (interleukin 12) by peripheral blood mononuclear cells. J. Exp. Med. 176: 1387-1398. | Trinchieri, G. et al. (2003) Interleukin-12 and the regulation of innate resistance and adaptive immunity. Nat. Rev. Immunol. 3 (2): 133-146. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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