CD275 (B7-H2), Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG

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Antigenic SpecificityCD275 (B7-H2), Mouse
CloneREA990
Host SpeciesRecombinant Human
Reactive Speciesmouse
IsotypeIgG1
FormatPE-Vio 770 conjugate
Size30 µg in 200 µL
Concentration1:50
ApplicationsFlow cytometry
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DescriptionCD275 (B7-H2) Antibody, anti-mouse, PE-Vio® 770, REAfinity™. Clone REA990 recognises the mouse CD275 antigen, which is also known as B7-H2 or ICOSL. CD275 is a type I membrane protein and belongs to the Ig superfamily, B7 family of co-stimulatory molecules. Expression of CD275 is found on antigen presenting cells such as B cells, dendritic cells, and monocytes. CD275 co-stimulates T cells upon binding to inducible T cell co-stimulator (ICOS), which is expressed on activated T cells. In mouse, CD275 binds only ICOS, whereas in humans it can interact with other T cell co-stimulatory molecules, CD28 and CTLA-4. To appropriately regulate the activation of immune response, the ICOS-CD275 interaction can also lead to downregulation of CD275 expression which allows prevention of hyperreaction of T cells. | Additional information: Clone REA990 displays negligible binding to Fc receptors.
Immunogenn/a
Other NamesICOSL, B7-H2, B7RP-1, B7h, ICOSLG, LICOS, Ly115l, GL50
Gene, Accession #Gene ID: 50723
Catalog #130-116-448
Price$156
Order / More InfoCD275 (B7-H2), Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG
Product Specific ReferencesWatanabe, M. et al. (2008) Down-regulation of ICOS ligand by interaction with ICOS functions as a regulatory mechanism for immune responses. J Immunol 180: 5222-5234. | Yao, S. et al. (2011) B7-H2 is a costimulatory ligand for CD28 in human. Immunity 34 (5): 729-740.
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-Straße 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197

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