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Antigenic Specificity | Siglec-10, Human |
Clone | REA1048 |
Host Species | Recombinant Human |
Reactive Species | human |
Isotype | IgG1 |
Format | phycoerythrin (PE) conjugate |
Size | 100 tests in 200 µL |
Concentration | 1:50 |
Applications | Flow cytometry |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Siglec-10 Antibody, anti-human, PE, REAfinity™. Clone REA1048 recognizes the human siglec-10 antigen, also known as sialic acid-binding Ig-like lectin 10, which is a member of the CD33-related group of siglecs. The cytoplasmic tail of siglec-10 contains four tyrosines, two of which are embedded in ITIM-signaling motifs and are likely to be involved in intracellular signaling. Amongst peripheral blood leucocytes, siglec-10 was found to be expressed on eosinophils, monocytes, and B cells. Higher levels of siglec-10 were found on a minor subset of NK-like cells that express the CD16 low-affinity Fc receptor but lack the CD56 antigen. The molecular properties and expression pattern suggest that siglec-10 may have evolved to function as an inhibitory receptor of the innate immune system. | Additional information: Clone REA1048 displays negligible binding to Fc receptors. |
Immunogen | n/a |
Other Names | PRO940, SLG2, Siglec10, Siglec-like protein 2 (SLG2) |
Gene, Accession # | Gene ID: 89790 |
Catalog # | 130-117-895 |
Price | $315 |
Order / More Info | Siglec-10, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
Product Specific References | Munday, J. et al. (2001) Identification, characterization, and leucocyte expression of siglec-10, a novel human sialic acid-binding receptor. Biochem. J. 355: 489-497. | Kitzig, F. et al. (2002) Cloning of two new splice variants of Siglec-10 and mapping of the interaction between Siglec-10 and SHP-1. Biochem. Biophys. Res. Commun. 296 (2): 355-362. | Bandala-Sanchez, E. et al. (2013) T cell regulation mediated by interaction of soluble CD52 with the inhibitory receptor Siglec-10. Nat Immunol 14 (7): 741-748. |