CD162, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | CD162, Human |
| Clone | REA319 |
| Host Species | Recombinant Human |
| Reactive Species | human |
| Isotype | IgG1 |
| Format | allophycocyanin (APC) conjugate |
| Size | 100 tests in 200 µL |
| Concentration | 1:50 |
| Applications | Flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | CD162 Antibody, anti-human, APC, REAfinity™. Clone REA319 recognizes the human CD162 antigen, a single-pass type I membrane protein which is also known as P-selectin glycoprotein ligand 1 (PSGL-1). CD162 is expressed on neutrophils, monocytes, and most lymphocytes. It is the high affinity receptor for CD62P (P-selectin) on myeloid cells and stimulated T lymphocytes and mediates rapid rolling of leukocytes over vascular surfaces during the initial steps in inflammation. CD162 is also involved in homeostasis including stem cell homing to the thymus and mature T cell homing to secondary lymphoid organs. It has been found to bind the homeostatic chemokines CCL19 and CCL21 and to support the chemotactic response to these chemokines. | Additional information: Clone REA319 displays negligible binding to Fc receptors. | | |
| Immunogen | n/a |
| Other Names | PSGL-1, SELPLG |
| Gene, Accession # | Gene ID: 9332 |
| Catalog # | 130-123-841 |
| Price | $335 |
| Order / More Info | CD162, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Frenette, P. S. et al. (2000) P-selectin glycoprotein ligand 1 (PSGL-1) is expressed on platelets and can mediate platelet-endothelial interactions in vivo. J. Exp. Med. 191 (8): 1413-1422. | Sako, D. et al. (1993) Expression cloning of a functional glycoprotein ligand for P-selectin. Cell 75 (6): 1179-1186. | Carlow, D. A. et al. (2009) PSGL-1 function in immunity and steady state homeostasis. Immunol. Rev. 230 (1): 75-96. | Evani, S. J. et al. (2016) Biophysical regulation of Chlamydia pneumoniae-infected monocyte recruitment to atherosclerotic foci. Sci Rep 6: . |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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