GATA3, Human/Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | GATA3, Human/Mouse |
| Clone | REA174 |
| Host Species | Recombinant Human |
| Reactive Species | human, mouse |
| Isotype | IgG1 |
| Format | fluorescein (FITC) conjugate |
| Size | 30 tests in 60 µL |
| Concentration | 1:50 |
| Applications | Intracellular flow cytometry, MICS (MACSima Imaging Cyclic Staining), Immunofluorescence, Immunohistochemistry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | GATA3 Antibody, anti-human/mouse, FITC, REAfinity™. Clone REA174 recognizes GATA3, a member of the GATA family of transcription factors. Like other members of the family, GATA3 contain zinc finger motifs involved in recognizing the canonical GATA DNA sequence. GATA3 has two trans-activating domains and two zinc finger domains, each followed by a conserved basic region. Expression of GATA3 is found in developing and mature T cells, natural killer (NK) cells, subset of NKT cells, and endothelial cells. Primary function attributed to GATA3 is to regulate the T helper 2 (T?2) cell differentiation. However, role of GATA3 is also recognized in early T cell commitment and CD4+ T cell development. | Additional information: Clone REA174 displays negligible binding to Fc receptors. ????? | |
| Immunogen | n/a |
| Other Names | HDR, HDRS, jal |
| Gene, Accession # | Gene ID: 2625 |
| Catalog # | 130-120-147 |
| Price | $93 |
| Order / More Info | GATA3, Human/Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Ho, I. et al. (2007) GATA-3 - not just for T?2 cells anymore. Cell. Mol. Immunol. 4 (1): 15-29. | Zaiss, D. M. et al. (2017) Epidermal growth factor receptor expression licenses type-2 helper T cells to function in a T cell receptor-independent fashion. Immunity 47 (4): 710-722. | Ting, C. N. et al. (1996) Transcription factor GATA-3 is required for development of the T-cell lineage. Nature 284 (6608): 474-478. | Joulin, V. et al. (1991) A T-cell specific TCR delta DNA binding protein is a member of the human GATA family. EMBO J. 10: 1809-1816. | Qian, L. et al. (2014) Alkylglycerols modulate the proliferation and differentiation of non-specific agonist and specific antigen-stimulated splenic lymphocytes. PLoS One 9 (4): e96207. | Martinelli, G. et al. (2018) Immunosuppressive Treg cells acquire the phenotype of effector-T cells in chronic lymphocytic leukemia patients. J. Transl. Med. 16 (1): 172. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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