MHC Class II (I-Ak), Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | MHC Class II (I-Ak), Mouse |
| Clone | REA610 |
| Host Species | Recombinant Human |
| Reactive Species | mouse |
| Isotype | IgG1 |
| Format | allophycocyanin (APC) conjugate |
| Size | 9 µg in 300 µL |
| Concentration | 1:10 |
| Applications | Flow cytometry, MICS (MACSima Imaging Cyclic Staining), Immunofluorescence, Immunohistochemistry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | MHC Class II (I-Ak) Antibody, anti-mouse, APC, REAfinity™. Clone REA610 recognizes the β chain of the mouse MHC class II alloantigen I-Ak of H-2k bearing mouse strains. It also cross-reacts with the H-2f, H-2r, and H-2s haplotypes, but reactivity to other haplotypes (i.e., b, d, p, and q) has not been observed. It also cross-reacts with splenocytes from nonobese diabetic (NOD) mice, and with lymph node cells of BN, DA, WRA, and WRC rats. MHC class II is expressed on antigen-presenting cells, such as dendritic cells, monocytes, macrophages, B cells in lymphoid and non-lymphoid tissue, thymic epithelial cells, and on subsets of hematopoietic progenitor cells in the bone marrow. | Additional information: Clone REA610 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | MHC class II IAk, Aβk, A beta K, Aalpha, H-2Aa, H2Aa, I-Aalpha, IAalpha |
| Gene, Accession # | Gene ID: 14960 |
| Catalog # | 130-109-351 |
| Price | $61 |
| Order / More Info | MHC Class II (I-Ak), Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Bhattacharya, A. et al. (1981) A shared alloantigenic determinant on Ia antigens encoded by the I-A and I-E subregions: evidence for I region gene duplication. J Immunol 127 (6): 2488-2495. | Nelson, C. A. et al. (1996) A negatively charged anchor residue promotes high affinity binding to the MHC class II molecule I-Ak. J Immunol 157 (2): 755-762. | Ting, J. P. et al. (2002) Genetic control of MHC class II expression. Cell 109: 21-33. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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