CD88 (C5AR), Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | CD88 (C5AR), Mouse |
| Clone | 20/70 |
| Host Species | Rat |
| Reactive Species | mouse |
| Isotype | IgG2bκ |
| Format | phycoerythrin (PE) conjugate |
| Size | 9 µg in 300 µL |
| Concentration | 1:10 |
| Applications | Flow cytometry, MICS (MACSima Imaging Cyclic Staining), Immunofluorescence, Immunohistochemistry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | CD88 (C5AR) Antibody, anti-mouse, PE. Clone 20/70 recognizes the mouse CD88 antigen, a 43 kDa G type protein-coupled receptor with seven membrane-spanning regions which is also known as C5a anaphylatoxin chemotactic receptor 1 (C5AR). CD88 is expressed on neutrophils and monocyte/macrophages, but it is also found on hepatocytes, epithelial cells, endothelial cells, tissue mast cells, and human fetal astrocytes. Constitutive CD88 expression was also detected on microglia and fibroblast-like cells but not by oligodendrocytes. CD88 is a receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. It stimulates chemotaxis, granule enzyme release, and superoxide anion production. Sulfation plays a critical role in the association of CD88 with C5a, but no significant role in the ability of CD88 to transduce a signal and mobilize calcium in response to a small peptide agonist. |
| Immunogen | n/a |
| Other Names | C5AR1, C5AR, C5R1, D7Msu1 |
| Gene, Accession # | Gene ID: 12273 |
| Catalog # | 130-106-174 |
| Price | $47 |
| Order / More Info | CD88 (C5AR), Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Gerard, C. et al. (1992) Structural diversity in the extracellular faces of peptidergic G-protein-coupled receptors. Molecular cloning of the mouse C5a anaphylatoxin receptor. J Immunol 149 (8): 2600-2606. | Sadik, C. D. et al. (2012) Neutrophils orchestrate their own recruitment in murine arthritis through C5aR and FcγR signaling. Proc. Natl. Acad. Sci. U.S.A. 109 (46): E3177-E3185. | Bosmann, M. et al. (2013) The interaction between C5a and both C5aR and C5L2 receptors is required for production of G-CSF during acute inflammation. Eur. J. Immunol. 43 (7): 1907-1913. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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