CD223, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | CD223, Human |
| Clone | REA351 |
| Host Species | Recombinant Human |
| Reactive Species | human |
| Isotype | IgG1 |
| Format | VioBlue conjugate |
| Size | 30 tests in 60 µL |
| Concentration | 1:50 |
| Applications | Flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | CD223 Antibody, anti-human, VioBlue®, REAfinity™. Clone REA351 recognizes the human CD223 antigen, a single-pass type I membrane protein also known as lymphocyte activation gene 3 protein (LAG-3). CD223 is a CD4 homolog with four extracellular Ig superfamily domains. Similar to CD4, CD223 oligomerizes at the surfaces of T cells and binds to MHC II on antigen presenting cells but with significantly higher affinity than CD4. CD223 is expressed on activated CD4+ and CD8+ T lymphocytes where it associates with the CD3-TCR complex at the cell surface and negatively regulates signal transduction. As a consequence, it negatively regulates T cell proliferation, function, and homeostasis. There is also increasing evidence of its involvement in regulatory function of tumor-infiltrated T cells in cancer, such as in Hodgkin's lymphomas and in prostate cancer. CD223 is also expressed on activated NK cells, B cells, and plasmacytoid dendritic cells. | Additional information: Clone REA351 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | LAG-3, Protein FDC |
| Gene, Accession # | Gene ID: 3902 |
| Catalog # | 130-118-677 |
| Price | $148 |
| Order / More Info | CD223, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Huang, C. T. et al. (2004) Role of LAG-3 in regulatory T cells. Immunity 21 (4): 503-513. | Triebel, F. et al. (1990) LAG-3, a novel lymphocyte activation gene closely related to CD4. J. Exp. Med. 171 (5): 1393-1405. | Gagliani, N. et al. (2013) Coexpression of CD49b and LAG-3 identifies human and mouse T regulatory type 1 cells. Nat Med 19 (6): 739-746. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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