CD48, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | CD48, Human |
| Clone | REA426 |
| Host Species | Recombinant Human |
| Reactive Species | human |
| Isotype | IgG1 |
| Format | VioBlue conjugate |
| Size | 100 tests in 200 µL |
| Concentration | 1:50 |
| Applications | Flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | CD48 Antibody, anti-human, VioBlue®, REAfinity™. Clone REA426 recognizes the human CD48 antigen, a glycosyl-phosphatidyl-inositol (GPI)-anchored cell-surface protein of the CD2 family of molecules, which is also known as B-lymphocyte activation marker BLAST-1, BCM1, MEM-102, or SLAM family member 2 (SLAMF2). CD48 is expressed on various hematopoietic cells and its expression is regulated by viral and bacterial products and immune-associated proteins. CD48 binds CD2 and other molecules, yet its high-affinity ligand in both mouse and human systems is CD244 (2B4). Despite its lack of an intracellular domain, stimulation of CD48 induces rearrangement of signaling factors in lipid rafts, Lck-kinase activity, and tyrosine phosphorylation. As an adhesion and co-stimulatory molecule, CD48 induces numerous effects in B and T lymphocytes, natural killer cells, mast cells, and eosinophils. Some of these depend upon cell-cell interactions via CD244-CD48 binding. | Additional information: Clone REA426 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | Blast-1, BCM1, BLAST, MEM-102, SLAMF2, hCD48, mCD48, Blast-1, TCT.1 |
| Gene, Accession # | Gene ID: 962 |
| Catalog # | 130-123-532 |
| Price | $345 |
| Order / More Info | CD48, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Tarakhovsky, A. et al. (1995) A role for CD5 in TCR-mediated signal transduction and thymocyte selection. Science 269 (5223): 535-537. | Efanov, A. et al. (2010) CD5+CD23+ leukemic cell populations in TCL1 transgenic mice show significantly increased proliferation and Akt phosphorylation. Leukemia 24 (5): 970-975. | Lundy, S. K. et al. (2014) Characterization and activity of Fas ligand producing CD5+ B cells. Methods Mol. Biol. 1190: 81-102. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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