Hsp70, Human/Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | Hsp70, Human/Mouse |
| Clone | REA349 |
| Host Species | Recombinant Human |
| Reactive Species | human, mouse |
| Isotype | IgG1 |
| Format | fluorescein (FITC) conjugate |
| Size | 100 tests in 200 µL |
| Concentration | 1:50 |
| Applications | Flow cytometry, MICS (MACSima Imaging Cyclic Staining), Immunofluorescence, Immunohistochemistry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Hsp70 Antibody, anti-human/mouse, FITC, REAfinity™. Clone REA349 recognizes the human and mouse heat shock 70 kDa protein (Hsp70) antigen, a member of the heat shock protein family that serve critical roles in protein homeostasis. The Hsp70 family is the most conserved in evolution, and all eukaryotes contain multiple members. Their synthesis is increased upon environmental stress. Hsp70 assists a wide range of folding processes, including the folding and assembly of newly synthesized proteins, refolding of misfolded and aggregated proteins, membrane translocation of organellar and secretory proteins, and control of the activity of regulatory proteins. It has thus housekeeping functions in the cell in which it is built-in components of folding and signal transduction pathways, and quality control functions in which it proofreads the structure of proteins and repairs misfolded conformers. All of these activities appear to be based on the property of Hsp70 to interact with hydrophobic peptide segments of proteins in an ATP-controlled fashion. | Additional information: Clone REA349 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | HSPA1B, HSPA1A, HSP70-1, HSP70-2, HSP70.1, HSP70.2 |
| Gene, Accession # | Gene ID: 3303, 3304 |
| Catalog # | 130-124-694 |
| Price | $270 |
| Order / More Info | Hsp70, Human/Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Murphy, M. E. et al. (2013) The HSP70 family and cancer. Carcinogenesis 34 (6): 1181-1188. | Milner, C. M. et al. (1990) Structure and expression of the three MHC-linked HSP70 genes. Immunogenetics 32 (4): 242-251. | Mayer, M. P. et al. (2005) Hsp70 chaperones: cellular functions and molecular mechanism. Cell. Mol. Life Sci. 62 (6): 670-684. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
Profile of MILTENYI BIOTEC B.V. & Co. KG