Edit |   |
---|---|
Antigenic Specificity | CD18, Human |
Clone | TS1/18 |
Host Species | Mouse |
Reactive Species | human, other |
Isotype | IgG1κ |
Format | fluorescein (FITC) conjugate |
Size | 30 tests in 60 µL |
Concentration | 1:50 |
Applications | Flow cytometry, MICS (MACSima Imaging Cyclic Staining), Immunofluorescence, Immunohistochemistry |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | CD18 Antibody, anti-human, FITC. Clone TS1/18 reacts with CD18, a type I transmembrane protein with an approximate molecular weight of 90-95 kDa. It non-covalently associates with α subunits CD11a (αL), CD11b (αM), CD11c (αX), and CD11d (αD) to form functional integrins which are expressed on leucocytes. CD18 associated integrins bind several ligands including cell surface and extracellular matrix proteins and are involved in cell-cell and cell-extracellular matrix interactions, immune regulation, and immune tolerance. Leucocytes of patients lacking CD18 or expressing dysfunctional CD18 are defective in chemotaxis, phagocytosis, and homotypic aggregation. |
Immunogen | n/a |
Other Names | ITGB2, CD18, LAD, LCAMB, LFA-1, Mac-1 α, MF17, MFI7 |
Gene, Accession # | n/a |
Catalog # | 130-120-322 |
Price | $92 |
Order / More Info | CD18, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
Product Specific References | Tan, S. M. (2012) The leucocyte β2 (CD18) integrins: the structure, functional regulation and signalling properties. Biosci. Rep. 32 (3): 241-269. |