Rae-1α/β/γ, Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | Rae-1α/β/γ, Mouse |
| Clone | REA578 |
| Host Species | Recombinant Human |
| Reactive Species | mouse |
| Isotype | IgG1 |
| Format | PE-Vio 770 conjugate |
| Size | 9 µg in 300 µL |
| Concentration | 1:10 |
| Applications | Flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Rae-1α/β/γ Antibody, anti-mouse, PE-Vio® 770, REAfinity™. Clone REA578 recognizes the Rae-1α/β/γ antigen, a surface protein and member of GPI-linked (glypiated) proteins which share partial homology with MHC class I molecules. Rae-1α/β/γ were detected in early mouse embryos, especially in the head region. Rae-1 is also up-regulated on a large variety of tumor cells. Together with H-60, Rae-1 is a ligand for the murine NKG2D receptor and a potent stimulator of innate immunity. The ligand-expressing tumour cells induce potent priming of cytotoxic T cells and sensitization of NK cells in vivo. Clone REA578 does not detect Rae-1δ/ε. | Additional information: Clone REA578 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | Mrnp41 |
| Gene, Accession # | Gene ID: 19368, 19369, 19370 |
| Catalog # | 130-109-068 |
| Price | $53 |
| Order / More Info | Rae-1α/β/γ, Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Diefenbach, A. et al. (2001) Rae1 and H60 ligands of the NKG2D receptor stimulate tumour immunity. Nature 413 (6852): 165-171. | Diefenbach, A. et al. (2000) Ligands for the murine NKG2D receptor: expression by tumor cells and activation of NK cells and macrophages. Nat Immunol 1 (2): 119-126. | Nomura, M. et al. (1996) Genomic structures and characterization of Rae1 family members encoding GPI-anchored cell surface proteins and expressed predominantly in embryonic mouse brain. J. Biol. Chem. 120 (5): 987-995. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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