CD120b (TNF-RII), Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | CD120b (TNF-RII), Mouse |
| Clone | REA228 |
| Host Species | Recombinant Human |
| Reactive Species | mouse |
| Isotype | IgG1 |
| Format | PE-Vio 770 conjugate |
| Size | 30 µg in 1 mL |
| Concentration | 1:10 |
| Applications | Flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | CD120b (TNF-RII) Antibody, anti-mouse, PE-Vio® 770, REAfinity™. Clone REA228 recognizes the extracellular part of the membrane-bound and truncated soluble form of the mouse CD120b antigen, a 75 kD type I transmembrane protein, which is also known as Tumor Necrosis Factor Receptor Type II (TNF-RII). CD120b is a receptor with high affinity for the mouse cytokine TNF-α and with lower affinity for LT-α. It belongs to the TNF receptor superfamily and is largely confined to cells of the immune system. CD120b is strongly expressed on stimulated T and B lymphocytes and on a variety of cells at low levels. Sustained activation of TNF signaling has been implicated in the pathogenesis of a wide spectrum of diseases, including cancer, osteoporosis, sepsis, diabetes, and autoimmune diseases such as multiple sclerosis, rheumatoid arthritis, and inflammatory bowel disease. Additional information: Clone REA228 displays negligible binding to Fc receptors. | |
| Immunogen | n/a |
| Other Names | TNFRSF1B, Tumor necrosis factor receptor 2 (TNF-R2), Tumor necrosis factor receptor type II (TNF-RII, TNFR-II), p75, p80 TNF-alpha receptor |
| Gene, Accession # | Gene ID: 21938 |
| Catalog # | 130-104-699 |
| Price | $156 |
| Order / More Info | CD120b (TNF-RII), Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | van Mierlo, G. J. et al. (2008) Cutting edge: TNFR-shedding by CD4+CD25+ regulatory T cells inhibits the induction of inflammatory mediators. J Immunol 180 (5): 2747-2751. | Lewis, M. et al. (1991) Cloning and expression of cDNAs for two distinct murine tumor necrosis factor receptors demonstrate one receptor is species specific. Proc. Natl. Acad. Sci. U.S.A. 88 (7): 2830-2834. | Al-Lamki, R. S. et al. (2013) TNF, acting through inducibly expressed TNFR2, drives activation and cell cycle entry of c-Kit+ cardiac stem cells in ischemic heart disease. Stem Cells 31 (9): 1881-1892. | Siegmund, D. et al. (2016) Activation of TNFR2 sensitizes macrophages for TNFR1-mediated necroptosis. Cell Death Dis 7 (9): e2375. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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