CD52, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
Search, find, compare suppliers for anti-CD52, Human antibody, protein, ELISA kits.
| Edit | |
|---|---|
| Antigenic Specificity | CD52, Human |
| Clone | REA164 |
| Host Species | Recombinant Human |
| Reactive Species | human |
| Isotype | IgG1 |
| Format | PE-Vio 770 conjugate |
| Size | 30 tests in 300 µL |
| Concentration | 1:11 |
| Applications | Flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | CD52 Antibody, anti-human, PE-Vio® 770, REAfinity™. Clone REA164 recognizes CD52, a glycosylphosphatidylinositol (GPI)-anchored, 25-29 kDa heavily glycosylated antigen. The CD52 core peptide is only 12 amino acids long and is linked to the surface via C-terminal GPI anchor. Expression of CD52 is found on lymphocytes, monocytes, macrophages, eosinophils, and in the male reproductive tract on the epithelial cells of the epididymis and seminal vesicle. CD52 is absent in immature spermatozoa in the efferent ducts but is acquired by the sperm membrane, progressively, as they pass through the epididymis proper, where CD52 is shed into the seminal plasma by the epididymis. Though the exact role of CD52 is unclear, antibodies against CD52 elicit antibody dependent cellular and complement mediated cytolysis of the CD52 expressing lymphocytes. Owing to this, such antibodies are often used to target malignant cells. CD52 expressed on sperms and on lymphocytes are basically different glycoforms of the same core peptide. | Additional information: Clone REA164 displays negligible binding to Fc receptors. | |
| Immunogen | n/a |
| Other Names | CDW52, CAMPATH-1 |
| Gene, Accession # | Gene ID: 1043 |
| Catalog # | 130-099-622 |
| Price | $162 |
| Order / More Info | CD52, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Ambrose, L. R. et al. (2009) Neutrophils express CD52 and exhibit complement-mediated lysis in the presence of alemtuzumab. Blood 114: 3052-3055. | Rawstron, A. C. et al. (2006) CD52 expression patterns in myeloma and the applicability of alemtuzumab therapy. Haematologica 91: 1577 -1578. | Yeung, C. H. et al. (1998) Epididymal secretion of CD52 as measured in human seminal plasma by a fluorescence immunoassay. Mol. Hum. Reprod. 4: 447-451. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
Profile of MILTENYI BIOTEC B.V. & Co. KG
Return to Antibodies