IL-12R β2, Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | IL-12R β2, Mouse |
| Clone | REA200 |
| Host Species | Recombinant Human |
| Reactive Species | mouse |
| Isotype | IgG1 |
| Format | APC-Vio 770 conjugate |
| Size | 30 µg in 200 µL |
| Concentration | 1:50 |
| Applications | Flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | IL-12R β2 Antibody, anti-mouse, APC-Vio® 770, REAfinity™. Clone REA200 recognizes the mouse Interleukin-12 receptor subunit beta-2 (IL-12R β2) antigen, a Single-pass type I membrane protein which forms the functional high affinity IL-12 receptor together with the IL-12R β1 subunit. While the IL-12R β1 subunit is constitutively expressed, the expression of the IL-12R β2 gene is up-regulated by interferon gamma. IL-12R β2 is expressed by Th1 cells and IL-12 signaling through the IL-12 receptor leads to the phosphorylation of STAT4 and continued Th1 differentiation. The IL-12R β2 subunit plays an important role in Th1 cell differentiation, since its absence leads to an abortive Th1 differentiation that has dysfunctional production of Th1 effector molecules. The up-regulation of IL-12R β2 is found to be associated with a number of infectious diseases, such as Crohn's disease and leprosy, which is thought to contribute to the inflammatory response and host defense. | Additional information: Clone REA200 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | IL12RB2, IL-12RB2, Ifnm |
| Gene, Accession # | Gene ID: 16162 |
| Catalog # | 130-125-861 |
| Price | $159 |
| Order / More Info | IL-12R β2, Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Nishikomori, R. et al. (2002) Activated STAT4 has an essential role in T?1 differentiation and proliferation that is independent of its role in the maintenance of IL-12R beta 2 chain expression and signaling. J Immunol 169 (8): 4388-4398. | Yin, Z. et al. (2000) Dominance of IL-12 over IL-4 in gamma delta T cell differentiation leads to default production of IFN-gamma: failure to down-regulate IL-12 receptor beta 2-chain expression. J Immunol 164 (6): 3056-3064. | Presky, D. H. et al. (1996) A functional interleukin 12 receptor complex is composed of two beta-type cytokine receptor subunits. Proc. Natl. Acad. Sci. U.S.A. 93 (24): 14002-14007. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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