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Antigenic Specificity | CD33, Human |
Clone | REA775 |
Host Species | Recombinant Human |
Reactive Species | human |
Isotype | IgG1 |
Format | PE-Vio 770 conjugate |
Size | 30 tests in 60 µL |
Concentration | 1:50 |
Applications | Flow cytometry |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | CD33 Antibody, anti-human, PE-Vio® 770, REAfinity™. Clone REA775 recognizes the human CD33 antigen, a 67 kDa glycoprotein belonging to the sialoadhesin superfamily. The CD33 antigen is highly expressed on human monocytes but weakly on granulocytes and some - but not all - myeloid dendritic cells. The CD33 antigen is also found on myeloid progenitor cells (CFU-GEMM, CFU GM, CFU-G, BFU-E) but is not expressed on lymphocytes, platelets, erythrocytes, or primitive hematopoietic stem cells. | Additional information: Clone REA775 displays negligible binding to Fc receptors. |
Immunogen | n/a |
Other Names | Siglec-3, p67, My9 |
Gene, Accession # | Gene ID: 945 |
Catalog # | 130-111-138 |
Price | $162 |
Order / More Info | CD33, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
Product Specific References | Simmons, D. et al. (1988) Isolation of a cDNA encoding CD33, a differentiation antigen of myeloid progenitor cells. J Immunol 141 (8): 2797-2800. | Bernstein, I. D. et al. (1987) Treatment of acute myeloid leukemia cells in vitro with a monoclonal antibody recognizing a myeloid differentiation antigen allows normal progenitor cells to be expressed. J. Clin. Invest. 79 (4): 1153-1159. | Hernandez-Caselles, T. et al. (2006) A study of CD33 (SIGLEC-3) antigen expression and function on activated human T and NK cells: two isoforms of CD33 are generated by alternative splicing. J. Leukoc. Biol. 79 (1): 46-58. | Soldierer, M. et al. (2022) Genetic Engineering and Enrichment of Human NK Cells for CAR-Enhanced Immunotherapy of Hematological Malignancies, Front Immunol 13: doi: 10.3389/fimmu.2022.847008. |