CD267 (TACI), Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | CD267 (TACI), Mouse |
| Clone | 8F10 |
| Host Species | Rat |
| Reactive Species | mouse |
| Isotype | IgG2aκ |
| Format | allophycocyanin (APC) conjugate |
| Size | 30 µg in 1 mL |
| Concentration | 1:10 |
| Applications | Flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | CD267 (TACI) Antibody, anti-mouse, APC. Clone 8F10 recognizes CD267, a type III transmembrane protein receptor that binds to APRIL and BAFF and also interacts with heparan sulfate proteoglycans (HSPGs). Expression of CD267 is found on subset of T cells, marzinal zone (MZ) and, B1 B cells. A dual role of TACI has been suggested in regulating B cell activation. TACI-/- mice have high number of hyper-reactive B cells, indicating an inhibitory role of TACI. On the other hand, mice lacking TACI are unable to mount normal T-cell independent type 2 (TI-2) immune response and thus suggesting a positive role in promoting B cell activation. |
| Immunogen | n/a |
| Other Names | TNFRSF13B, TACI |
| Gene, Accession # | Gene ID: 57916 |
| Catalog # | 130-102-722 |
| Price | $88 |
| Order / More Info | CD267 (TACI), Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Batten, M. et al. (2004) TNF deficiency fails to protect BAFF transgenic mice against autoimmunity and reveals a predisposition to B cell lymphoma. J Immunol 172: 812-822. | Yan, M. et al. (2001) Activation and accumulation of B cells in TACI-deficient mice. Nat Immunol 2 (7): 638-643. | Mackay, F. et al. (2008) TACI, an enigmatic BAFF/APRIL receptor, with new unappreciated biochemical and biological properties. Cytokine Growth Factor Rev. 19 (3-4): 263-276. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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