TCR Vδ1, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | TCR Vδ1, Human |
| Clone | REA173 |
| Host Species | Recombinant Human |
| Reactive Species | human |
| Isotype | IgG1 |
| Format | biotin conjugate |
| Size | 100 tests in 200 µL |
| Concentration | 1:50 |
| Applications | Flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | TCR Vδ1 Antibody, anti-human, Biotin, REAfinity™. Clone REA173 recognizes the Vδ1 chain of γδ T cell receptor (TCR). The TCR δ locus is located within the TCR α locus on chromosome 14 and 6 Vδ segments have been reported so far. γδ T cells comprise a small population of T cells and unlike peripheral circulating αβ T cells, γδ T cells are mainly found in body tissues such as thymus, peripheral lymphoid tissues, intestinal epithelium, and epidermis. Distribution analysis in human oral cavity revealed preferential localisation of Vδ1+ γδ T cells in intraepithelial region. | Additional information: Clone REA173 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | TRDV1, hDV101S1 |
| Gene, Accession # | Gene ID: 28518 |
| Catalog # | 130-120-439 |
| Price | $270 |
| Order / More Info | TCR Vδ1, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Di Marco Barros, R. et al. (2016) Epithelia use butyrophilin-like molecules to shape organ-specific γδ T cell compartments. Cell 167 (1): 203-218. | Libero, G. D. et al. (1997) Sentinel function of broadly reactive human gamma delta T cells. Immunol. Today 18 (1): 22-26. | Pepin, L. F. et al. (1993) Preferential V delta 1 expression among TcR gamma/delta-bearing T cells in human oral epithelium. Scand. J. Immunol. 37 (3): 289-294. | Siegers, G. et al. (2018) Functional plasticity of gamma delta T cells and breast tumor targets in hypoxia. Front Immunol 9: . | Hunter, S. et al. (2018) Human liver infiltrating γδ T cells are composed of clonally expanded circulating and tissue-resident populations. J. Hepatol. 69 (3): 654-665. | Zumwalde, N. A. et al. (2016) Analysis of immune cells from human mammary ductal epithelial organoids reveals Vδ2+ T cells that efficiently target breast carcinoma cells in the presence of bisphosphonate. Cancer Prev Res (Phila) 9: 305-316. | Davey, M. S. et al. (2017) Clonal selection in the human Vδ1 T cell repertoire indicates γδ TCR-dependent adaptive immune surveillance. Nat Commun. 8: 14760. | Davey, M. et al. (2018) The human Vδ2+ T-cell compartment comprises distinct innate-like Vγ9+ and adaptive Vγ9- subsets. Nat Commun. 9 (1): . |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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