Integrin β7, Human/Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | Integrin β7, Human/Mouse |
| Clone | REA441 |
| Host Species | Recombinant Human |
| Reactive Species | human, mouse |
| Isotype | IgG1 |
| Format | biotin conjugate |
| Size | 30 tests in 300 µL |
| Concentration | 1:11 |
| Applications | Flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Integrin β7 Antibody, anti-human/mouse, Biotin, REAfinity™. Clone REA441 recognizes the human and mouse integrin β7 antigen, a single-pass type I membrane protein which is also known as gut homing receptor β subunit. Integrins are heterodimeric glycoprotein receptors and exist as non-covalently bound α and β subunits. The integrin β7 subfamily has two known members (α4β7 and αEβ7) that are expressed primarily by leukocytes and have been implicated in secondary lymphoid structure formation, plasma cells homing to gastrointestinal mucosa, and inflammatory responses. Their ligands: the mucosal vascular addressin cell adhesion molecule 1 (MAdCAM-1) and E-cadherin are present on the surface of endothelial cells, bone marrow stromal cells, and epithelial cells. Interaction of α4β7 with MAdCAM-1 allows for tissue-specific migration of circulating lymphocytes into the lamina propria and Peyer patches of the gut, whereas αEβ7 retains intraepithelial lymphocytes within the gut epithelium through E-cadherin binding. Integrin β7 is also reported to be involved in the pathogenesis of several diseases such as colitis, diabetic insulitis, and lymphoid malignancies including lymphomatous polyposis in mantle cell lymphoma, thymic lymphoma, and mucosa-associated T cell and B cell non-Hodgkin lymphomas. | Additional information: Clone REA441 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | ITGB7, Ly69, M290 IEL |
| Gene, Accession # | Gene ID: 16421 |
| Catalog # | 130-106-487 |
| Price | $99 |
| Order / More Info | Integrin β7, Human/Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Alles, M. et al. (2014) Leukocyte β7 integrin targeted by Kruppel-like factors. J Immunol 193 (4): 1737-1746. | Neri, P. et al. (2011) Integrin β7-mediated regulation of multiple myeloma cell adhesion, migration, and invasion. Blood 117 (23): 6202-6213. | Hu, M. C. et al. (1992) Cloning and expression of mouse integrin beta p(beta 7): a functional role in Peyer's patch-specific lymphocyte homing. Proc. Natl. Acad. Sci. U.S.A. 89 (17): 8254-8258. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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