Myosin Heavy Chain, Human/Mouse/Rat Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | Myosin Heavy Chain, Human/Mouse/Rat |
| Clone | REA399 |
| Host Species | Recombinant Human |
| Reactive Species | human, mouse, rat, other |
| Isotype | IgG1 |
| Format | purified |
| Size | 100 µg in 100 µL |
| Concentration | n/a |
| Applications | MICS (MACSima Imaging Cyclic Staining), Immunofluorescence, Immunohistochemistry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Myosin Heavy Chain Antibody, anti-human/mouse/rat, pure, REAfinity™. Clone REA399 recognizes the human, mouse, and rat cardiac isoform of the myosin heavy chain (MHC) antigen. Myosin forms cross-bridges with actin in cardiac, smooth, and skeletal muscle, and cyclic cross-bridge activity is the basis for muscular contraction. It is a hexamer composed of two heavy chains, each of which contains an actin-binding site and an ATP hydrolysis site, and four light chains. Isoforms of each myosin subunit are expressed in cardiac, skeletal, and smooth muscle, and many are associated with distinct contractile properties in the muscles or single muscle fibers in which they are expressed. In cardiac muscle, two MHC isoforms, termed α-MHC and β-MHC, are present. α-MHC is associated with higher actomyosin ATPase activity compared with β-MHC. The relative amounts of the two isoforms may vary, with the ratio being a function of the hormonal status, the developmental stage, the animal, or the particular region of the heart. | Additional information: Clone REA399 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | MYH6, MYH7, MHC, MYHC |
| Gene, Accession # | Gene ID: 4624, 4625 |
| Catalog # | 130-112-757 |
| Price | $148 |
| Order / More Info | Myosin Heavy Chain, Human/Mouse/Rat Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Cosper, P. F. et al. (2012) Interferon-γ causes cardiac myocyte atrophy via selective degradation of myosin heavy chain in a model of chronic myocarditis. Am. J. Pathol. 181 (6): 2038-2046. | Haddad, F. et al. (2010) Cardiac myosin heavy chain gene regulation by thyroid hormone involves altered histone modifications. Am. J. Physiol. Heart Circ. Physiol. 299 (6): H1968-H1980. | Molkentin, J. D. et al. (1996) Alpha-myosin heavy chain gene regulation: delineation and characterization of the cardiac muscle-specific enhancer and muscle-specific promoter. J. Mol. Cell. Cardiol. 28 (6): 1211-1225. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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