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Antigenic Specificity | CD110, Human |
Clone | REA250 |
Host Species | Recombinant Human |
Reactive Species | human |
Isotype | IgG1 |
Format | allophycocyanin (APC) conjugate |
Size | 30 tests in 60 µL |
Concentration | 1:50 |
Applications | Flow cytometry |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | CD110 Antibody, anti-human, APC, REAfinity™. Clone REA250 recognizes the CD110 antigen, a type I transmembrane protein and a member of the hematopoietin receptor family, which is also known as myeloproliferative leukemia protein (MPL) or thrombopoietin receptor (TPO-R). CD110 is expressed on hematopoietic stem cells, a subfraction of hematopoietic precursor cells, cells of the megakaryocytic lineage, and platelets. It serves as a receptor for thrombopoietin and CD110 deficiency leads to severe thrombocytopenia, emphasizing the important role of CD110 and thrombopoietin in megakaryocyte and platelet formation. | Additional information: Clone REA250 displays negligible binding to Fc receptors. | | |
Immunogen | n/a |
Other Names | MPL, C-MPL, MPLV, THCYT2, TPOR |
Gene, Accession # | Gene ID: 4352 |
Catalog # | 130-128-313 |
Price | $149 |
Order / More Info | CD110, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
Product Specific References | Vigon, I. et al. (1992) Molecular cloning and characterization of MPL, the human homolog of the v-mpl oncogene: identification of a member of the hematopoietic growth factor receptor superfamily. Proc. Natl. Acad. Sci. U.S.A. 89: 5640 -5644. | Chou, F. S. et al. (2011) The thrombopoietin/MPL pathway in hematopoiesis and leukemogenesis. J. Cell. Biochem. 112 (6): 1491-1498. | Kaushansky, K. et al. (1998) The role of the MPL receptor in myeloproliferative disorders. Leukemia 12: S47-S50. |