TCL1, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | TCL1, Human |
| Clone | REA289 |
| Host Species | Recombinant Human |
| Reactive Species | human |
| Isotype | IgG1 |
| Format | fluorescein (FITC) conjugate |
| Size | 30 tests in 60 µL |
| Concentration | 1:50 |
| Applications | Intracellular flow cytometry, MICS (MACSima Imaging Cyclic Staining), Immunofluorescence, Immunohistochemistry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | TCL1 Antibody, anti-human, FITC, REAfinity™. Clone REA289 recognizes the T cell leukemia/lymphoma protein, a 14 kDa symmetrical b-barrel structure protein also known as oncogene TCL-1 or protein p14 TCL1. The TCL1 locus on chromosome 14q32.1 is frequently involved in chromosomal translocations and inversions with one of the T cell receptor loci in human T cell leukemias and lymphomas. In the lymphoid compartment, TCL1 expression is limited to CD4-CD8-CD3- thymocytes, CD34+CD19+ pro-B cell through IgM-negative pre-B cells, as well as plasmacytoid subset of dendritic cells. The members of the TCL1 proto-oncogene family (TCL1, MTCP1, and TCL1b) bind to Akt1, increasing its phosphorylation status and kinase activity. Further, TCL1 is able to promote the formation of oligomeric TCL1-Akt protein complexes in which the kinase is preferentially phosphorylated and activated. | Additional information: Clone REA289 displays negligible binding to Fc receptors. | |
| Immunogen | n/a |
| Other Names | TCL1A, SYN-1, TML1, TCL1B |
| Gene, Accession # | Gene ID: 8115, 9623 |
| Catalog # | 130-126-540 |
| Price | $106 |
| Order / More Info | TCL1, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Virgilio, L. et al. (1994) Identification of the TCL1 gene involved in T-cell malignancies. Proc. Natl. Acad. Sci. U.S.A. 91 (26): 12530-12534. | Laine, J. et al. (2002) Differential regulation of Akt kinase isoforms by the members of the TCL1 oncogene family. J. Biol. Chem. 277 (5): 3743-3751. | Laine, J. et al. (2000) The protooncogene TCL1 is an Akt kinase coactivator. Mol. Cell 6 (2): 395-407. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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