CD328 (Siglec-7), Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | CD328 (Siglec-7), Human |
| Clone | REA214 |
| Host Species | Recombinant Human |
| Reactive Species | human |
| Isotype | IgG1 |
| Format | allophycocyanin (APC) conjugate |
| Size | 30 tests in 300 µL |
| Concentration | 1:11 |
| Applications | Flow cytometry, MICS (MACSima Imaging Cyclic Staining), Immunofluorescence, Immunohistochemistry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | CD328 (Siglec-7) Antibody, anti-human, APC, REAfinity™. Clone REA214 recognizes CD328, which is a member of sialic acid-binding immunoglobulin-like lectins (siglecs) family of trans-membrane proteins. Upon recognizing their natural ligands, the sialylated carbohydrates, siglecs generally transmit an inhibitory signal. CD328 is a 75 kDa type I trans-membrane protein and further belongs to the human CD33-related siglec receptors with sialic acid binding N-terminal Ig domain, two C2-set Ig domains, and a cytoplasmic region containing one immune-receptor tyrosine based inhibitory motif (ITIM) and one ITIM-like motif. Expression of CD328 is found on natural killer (NK) cells, monocytes, and on a small subset of CD8+/CD3+ T cells and it preferentially binds (2,8)-linked disialic acids and branched 2,6-sialyl residues. | Additional information: Clone REA214 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | AIRM1, CDw328, D-siglec, QA79, Siglec-7, SIGLEC19P, SIGLECP2, p75, p75/AIRM1 |
| Gene, Accession # | Gene ID: 27036 |
| Catalog # | 130-101-013 |
| Price | $142 |
| Order / More Info | CD328 (Siglec-7), Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Attrill, H. et al. (2006) Siglec-7 undergoes a major conformational change when complexed with the (2,8)-disialylganglioside GT1. J. Biol. Chem. 281: 32774-32783. | Angata, T. et al. (2000) Siglec-7: a sialic acid-binding lectin of the immunoglobulin superfamily. Glycobiology 10: 431-438. | Madge, P. D. et al. (2016) Structural characterisation of high affinity Siglec-2 (CD22) ligands in complex with whole Burkitt's lymphoma (BL) Daudi cells by NMR spectroscopy. Sci Rep 6: 36012. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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