p16, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | p16, Human |
| Clone | REA973 |
| Host Species | Recombinant Human |
| Reactive Species | human |
| Isotype | IgG1 |
| Format | allophycocyanin (APC) conjugate |
| Size | 30 tests in 60 µL |
| Concentration | 1:50 |
| Applications | Intracellular flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | p16 Antibody, anti-human, APC, REAfinity™. Clone REA973 recognizes the human p16 protein, a member of the cyclin-dependent kinases (CDKs), also known as cyclin-dependent kinase 4 inhibitor (CDKN2) or INK4A. p16 is a multiple tumor-suppressor protein that functions as a negative regulator of the proliferation of normal cells and tumorigenesis by forming heterodimers with CDK4 and CDK6. p16 is found in most of different cell types but it is not detected in brain or skeletal muscle. | Additional information: Clone REA973 displays negligible binding to Fc receptors |
| Immunogen | n/a |
| Other Names | p16-INK4, p16-INK4A, ARF, MTS1, CDKN2, CDK4l |
| Gene, Accession # | Gene ID: 1029 |
| Catalog # | 130-116-241 |
| Price | $140 |
| Order / More Info | p16, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Serrano, M. et al. (1993) A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4. Nature 366 (6456): 704-707. | Okamoto, A. et al. (1994) Mutations and altered expression of p16INK4 in human cancer. Proc. Natl. Acad. Sci. U.S.A. 91 (23): 11045-11049. | Bockstaele, L. et al. (2006) Regulated activating Thr172 phosphorylation of cyclin-dependent kinase 4(CDK4): its relationship with cyclins and CDK "inhibitors". Mol. Cell. Biol. 26 (13): 5070-5085. | Huang, X. et al. (2007) Identification and characterization of a novel protein ISOC2 that interacts with p16INK4a. Biochem. Biophys. Res. Commun. 361 (2): 287-293. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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