CD314 (NKG2D), Rat Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | CD314 (NKG2D), Rat |
| Clone | REA471 |
| Host Species | Recombinant Human |
| Reactive Species | rat |
| Isotype | IgG1 |
| Format | Vio Bright FITC conjugate |
| Size | 30 µg in 1 mL |
| Concentration | 1:10 |
| Applications | Flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | CD314 (NKG2D) Antibody, anti-rat, Vio® Bright FITC, REAfinity™. Clone REA471 recognizes the rat CD314 antigen, a single-pass type II membrane homodimeric glycoprotein belonging to the C-type lectin-like receptor family, which is also known as NKG2-D type II integral membrane protein (NKG2D) or killer cell lectin-like receptor subfamily K member 1 (Klrk1). Rat CD314 is expressed in NK cells, and is strongly expressed in resting CD8+ and CD4+ T cells, but not by thymocytes or other hemopoietic cells. It functions as an activating and costimulatory receptor involved in immunosurveillance upon binding to various cellular stress-inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. CD314 provides both, stimulatory and costimulatory innate immune responses on activated killer cells, leading to cytotoxic activity. It acts as a costimulatory receptor for T cell-receptor in CD8+ T cell-mediated adaptive immune responses by amplifying T cell-activation. Ligands of CD314 belong to various subfamilies of MHC class I-related glycoproteins. | Additional information: Clone REA471 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | Klrk1, Nkg2d, NKLLR, NKR-P2, NKR-P2, NKG2D |
| Gene, Accession # | Gene ID: 24934 |
| Catalog # | 130-106-929 |
| Price | $187 |
| Order / More Info | CD314 (NKG2D), Rat Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Berg, S. F. et al. (1998) Molecular characterization of rat NKR-P2, a lectin-like receptor expressed by NK cells and resting T cells. Int. Immunol. 10 (4): 379-385. | Flornes, L. M. et al. (2010) The complete inventory of receptors encoded by the rat natural killer cell gene complex. Immunogenetics 62 (8): 521-530. | Lai, C. B. et al. (2009) Creation of the two isoforms of rodent NKG2D was driven by a B1 retrotransposon insertion. Nucleic Acids Res. 37 (9): 3032-3043. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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