CD354 (TREM-1), Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG
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|---|---|
| Antigenic Specificity | CD354 (TREM-1), Mouse |
| Clone | REA191 |
| Host Species | Recombinant Human |
| Reactive Species | mouse |
| Isotype | IgG1 |
| Format | biotin conjugate |
| Size | 30 µg in 1 mL |
| Concentration | 1:10 |
| Applications | Flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | CD354 (TREM-1) Antibody, anti-mouse, Biotin, REAfinity™. Clone REA191 recognizes murine CD354 (TREM-1), a 30 KDa member of TREM (triggering receptors expressed on myeloid cells) family of cell surface receptors. TREM receptors are immunoglobulin 'superfamily' members and contain a single variable-type immunoglobulin domain. Murine TREM cluster is located on chromosome 17C. Expression of TREM-1 is found on cell surface of myeloid cells such as neutrophils, monocytes, dendritic cells and macrophages. TREM-1 signals via ITAM-containing adaptor DAP12 and serves as an amplifier of cell activation in response to triggers such as LPS. TREM-1 activated cellular signalling molecules and pathways lead to generation of pro-inflammatory response such as expression and secretion of chemokines and cytokines including MCP-1, MIP-1α, IL-6,-8 TNF. TREM-1 acts in a concerted manner with other signalling receptors as TLRs and Nod-like receptors, leading to an amplification of initial response. Expression of TREM-1 itself is upregulated in response to presence of LPS, microbial products and cytokines released during activation response. A soluble form of TREM-1 (sTREM-1) is also detected in serum of mouse infection, sepsis and granulomatous disease models. | Additional Information: Clone REA191 displays negligible binding to Fc receptors. | |
| Immunogen | n/a |
| Other Names | TREM1 |
| Gene, Accession # | Gene ID: 58217 |
| Catalog # | 130-101-857 |
| Price | $57 |
| Order / More Info | CD354 (TREM-1), Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Arts, R. J. W. et al. (2013) TREM-1: intracellular signaling pathways and interaction with pattern recognition receptors. J. Leukoc. Biol. 93: 209-215. | Wu, M. et al. (2011) TREM-1 amplifies corneal inflammation after Pseudomonas aeruginosa infection by modulating Toll-like receptor signaling and T?1/T?2-Type immune responses. Infect. Immun. 79: 2709 -2716. | Ferat-Osorio, E. et al. (2008) The increased expression of TREM-1 on monocytes is associated with infectious and noninfectious inflammatory processes. J Surg Res 150 (1): 110-117. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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