PLC-γ2, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | PLC-γ2, Human |
| Clone | REA488 |
| Host Species | Recombinant Human |
| Reactive Species | human, mouse |
| Isotype | IgG1 |
| Format | allophycocyanin (APC) conjugate |
| Size | 100 tests in 1 mL |
| Concentration | 1:11 |
| Applications | Mass cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | PLC-γ2 Antibody, anti-human, APC, REAfinity™. Clone REA488 recognizes the human phosphoinositide phospholipase C-γ-2 (PLC-γ2) antigen regardless of phosphorylation status. PLC-γ isoforms are mainly regulated through receptors with intrinsic tyrosine kinase activity (e.g. growth factor receptors) or receptors (such as B and T cell-antigen receptors) that are linked to the activation of non-receptor tyrosine kinases through a complex signaling network. The two isoforms of PLC-γ have distinct tissue distributions. Whereas PLC-γ1 is expressed ubiquitously, the pattern of expression of PLC-γ2 is characterized by high levels in cells of hematopoietic origin. PLC-γ2 is a transmembrane signaling enzyme that catalyzes the conversion of phosphatidyl inositol biphosphate to inositol triphosphate (IP3) and diacylglycerol (DAG) using calcium as a cofactor. It has been implicated in collagen-induced signal transduction in platelets and antigen-dependent signaling in B lymphocytes. PLC-γ2 is regulated through activation of tyrosine kinase-linked receptors. Homozygous disruption of PLC-γ2 results in functional and signaling disorders in a subset of cell types including B cells, platelets, and mast cells. | Additional information: Clone REA488 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | PLCG2, APLAID, FCAS3, PLC-IV, PLC-gamma-2 |
| Gene, Accession # | Gene ID: 5336 |
| Catalog # | 130-107-602 |
| Price | $325 |
| Order / More Info | PLC-γ2, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Hikida, M. et al. (2009) PLC-gamma2 is essential for formation and maintenance of memory B cells. J. Exp. Med. 206 (3): 681-689. | Ohta, S. et al. (1988) Complete cDNA encoding a putative phospholipase C from transformed human lymphocytes. FEBS Lett. 242 (1): 31-35. | Feng, L. et al. (2012) The effect of PLC-γ2 inhibitors on the growth of human tumour cells. Eur J Med Chem 54: 463-469. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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