Oct3/4 Isoform A, Human/Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG
Search, find, compare suppliers for anti-Oct3/4 Isoform A, Human/Mouse antibody, protein, ELISA kits.
| Edit | |
|---|---|
| Antigenic Specificity | Oct3/4 Isoform A, Human/Mouse |
| Clone | REA338 |
| Host Species | Recombinant Human |
| Reactive Species | human, mouse |
| Isotype | IgG1 |
| Format | phycoerythrin (PE) conjugate |
| Size | 100 tests in 200 µL |
| Concentration | 1:50 |
| Applications | Intracellular flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Oct3/4 Isoform A Antibody, anti-human/mouse, PE, REAfinity™. Clone REA338 recognizes the human octamer-binding transcription factor 3/4 isoform A (Oct3/4A) and the mouse Oct3/4. Oct3/4 is a homeodomain transcription factor belonging to the POU transcription factor family and is also known as POU domain class 5 transcription factor 1 (POU5F1). Oct3/4 is critical for the maintenance of totipotency in primate blastomeres and for pluripotency of the inner cell mass of developing mammalian embryos. This critical role of Oct3/4 is maintained in embryonic stem cells, the developing germline, and germline tumors, such as seminomas and embryonic teratocarcinomas. When inducing pluripotency in differentiated cells, Oct3/4 appears to be an essential, but not the only required transcription factor. Oct3/4 acts as a transcriptional activator of genes involved in maintenance of undifferentiated state and as a repressor of differentiation-specific genes.In human it encodes two chief isoforms that are generated by alternative splicing - Oct3/4A and Oct3/4b. Only the Oct3/4A protein consequently contains the unique N-terminal transactivation domain that regulates DNA binding of Oct3/4A to target promoters. It is only this full length Oct3/4A protein - that localizes to the nucleus, binds to Oct3/4-regulated promoters, and contributes to the maintenance of pluripotency and self-renewal. | Additional information: Clone REA338 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | POU5F1, OTF-3, OTF-4, Oct-3, Oct-4, Oct3/4A, Oct-3A, NF-A3 |
| Gene, Accession # | Gene ID: 5460 |
| Catalog # | 130-123-771 |
| Price | $305 |
| Order / More Info | Oct3/4 Isoform A, Human/Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Nakagawa, E. et al. (2012) The novel function of Oct3/4 in mouse tooth development. Histochem. Cell Biol. 137 (3): 367-376. | Niwa, H. et al. (2000) Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation or self-renewal of ES cells. Nat. Genet. 24 (4): 372-376. | Wey, E. et al. (1994) A human POU domain gene, mPOU, is expressed in developing brain and specific adult tissues. Eur. J. Biochem. 220 (3): 753-762. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
Profile of MILTENYI BIOTEC B.V. & Co. KG