CD344 (Frizzled-4), Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | CD344 (Frizzled-4), Human |
| Clone | REA1096 |
| Host Species | Recombinant Human |
| Reactive Species | human |
| Isotype | IgG1 |
| Format | PE-Vio 770 conjugate |
| Size | 30 tests in 60 µL |
| Concentration | 1:50 |
| Applications | Flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | CD344 (Frizzled-4) Antibody, anti-human, PE-Vio® 770, REAfinity™. Clone REA1096 recognizes an extracellular epitope of the human CD344 antigen, a multi-pass membrane protein which is also known as Frizzled family receptor 4 (FZD4) or Frizzled-4. CD344 is expressed by neuronal stem cells and also found on fetal neuronal progenitor cells and neuronal intestinal cells. It is a member of the Frizzled family of proteins which encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. CD344 is involved in the activation of Wnt/β-catenin pathway (canonic Wnt signaling). It is the only representative of frizzled family members that binds strongly an additional ligand Norrin that is functionally similar but structurally different from Wingless type proteins. CD344 signaling induced by Norrin regulates vascular development of vertebrate retina and controls important blood vessels in the ear. | Additional information: Clone REA1096 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | Fz-4, hFz4, FzE4, FZD4, Fz4, GPCR |
| Gene, Accession # | Gene ID: 8322 |
| Catalog # | 130-118-720 |
| Price | $170 |
| Order / More Info | CD344 (Frizzled-4), Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Kirikoshi, H. et al. (1999) Molecular cloning and characterization of human Frizzled-4 on chromosome 11q14-q21. Biochem. Biophys. Res. Commun. 264 (3): 955-961. | Ye, X. et al. (2009) Norrin, frizzled-4, and Lrp5 signaling in endothelial cells controls a genetic program for retinal vascularization. Cell 139 (2): 285-298. | Descamps, B. et al. (2012) Frizzled 4 regulates arterial network organization through noncanonical Wnt/planar cell polarity signaling. Circ. Res. 110 (1): 47-58. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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