CD220, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | CD220, Human |
| Clone | REA260 |
| Host Species | Recombinant Human |
| Reactive Species | human |
| Isotype | IgG1 |
| Format | allophycocyanin (APC) conjugate |
| Size | 100 tests in 1 mL |
| Concentration | 1:11 |
| Applications | Flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | CD220 Antibody, anti-human, APC, REAfinity™. Clone REA260 recognizes the CD220 antigen, a type I transmembrane receptor tyrosine kinase, which is also known as insulin receptor (IR). CD220 is predominantly expressed in major target tissues of insulin metabolic effects like liver, adipose tissue, and skeletal muscle, but is also expressed in the peripheral nerve, kidney, fibroblasts, monocytes, granulocytes, erythrocytes, and skin. It is composed of two extracellular α-subunits and two transmembrane β-subunits. Upon binding of insulin, CD220 forms a heterotetramer of two units to induce autophosphorylation and activation of the tyrosine kinase activity of the receptor. CD220 plays a key role in the regulation of glucose homeostasis, cell growth, differentiation, and apoptosis- functional processes that under degenerate conditions may result in a range of clinical manifestations including diabetes and cancer. | Additional information: Clone REA260 displays negligible binding to Fc receptors. | |
| Immunogen | n/a |
| Other Names | INSR, HHF5 |
| Gene, Accession # | Gene ID: 3643 |
| Catalog # | 130-103-653 |
| Price | $325 |
| Order / More Info | CD220, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Youngren, J. F. et al. (2007) Regulation of insulin receptor function. Cell. Mol. Life Sci. 64 (7-8): 873-891. | Czech, M. P. et al. (1985) The nature and regulation of the insulin receptor: structure and function. Annu. Rev. Physiol. 47: 357-381. | Chiu, S. L. et al. (2010) Insulin receptor signaling in the development of neuronal structure and function. Neural Dev. 5: 7. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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