AKT1, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG

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Antigenic SpecificityAKT1, Human
CloneREA134
Host SpeciesRecombinant
Reactive Specieshuman
IsotypeIgG1
FormatPerCP-Vio® 700 conjugate
Size30 tests in 300 µL
Concentration1:11
ApplicationsIntracellular flow cytometry
Reviews / RatingsIf you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY.
DescriptionAKT1 Antibody, anti-human, PerCP-Vio® 700, REAfinity™. Clone REA134 recognizes AKT1, which is also known as protein kinase Bα. AKT1 is a serine/threonine protein kinase, belonging to the AKT family of kinases and like each AKT family member, contains an N-terminal pleckstrin homology (PH) domain, a central kinase domain, and a carboxyl-terminal regulatory domain with a hydrophobic motif (HM). Activation of AKT1 is achieved via phosphorylation at multiple sites, which take place in response to engagement of receptors such as platelet derived growth factor receptor (PDGF-R). Activated AKT1 further phosphorylates and alters the activity of several downstream substrates allowing AKT1 to play a vital role in various biological processes such as cell growth, survival, migration, and proliferation. | Additional information: Clone REA134 displays negligible binding to Fc receptors. |
Immunogenn/a
Other NamesAKT, CWS6, PKB, PRKBA, RAC, RAC-ALPHA, PKBα
Gene, Accession #n/a
Catalog #130-100-744
Priceplease inquire
Order / More InfoAKT1, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
Product Specific ReferencesCalamito, M. et al. (2010) Akt1 and Akt2 promote peripheral B-cell maturation and survival. Blood 115: 4043-4050. | Arranz, A. et al. (2012) Akt1 and Akt2 protein kinases differentially contribute to macrophage polarization. Proc. Natl. Acad. Sci. U.S.A. 109 (24): 9517-9522.
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-Straße 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197

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