Lck pY505, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | Lck pY505, Human |
| Clone | REA673 |
| Host Species | Recombinant Human |
| Reactive Species | human, mouse, other |
| Isotype | IgG1 |
| Format | allophycocyanin (APC) conjugate |
| Size | 100 tests in 1 mL |
| Concentration | 1:11 |
| Applications | Flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Lck pY505 Antibody, anti-human, APC, REAfinity™. Clone REA673 recognizes the human Lck antigen, phosphorylated at tyrosine 505. Lck is a non-receptor tyrosine-protein kinase that plays an essential role in the selection and maturation of developing T cells in the thymus and in the function of mature T cells. It is expressed at all stages of thymocyte development and is required for the regulation of maturation events that are governed by both pre-TCR and mature α/β TCR. Lck plays a key role in the T cell antigen receptor (TCR)-linked signal transduction pathways and is constitutively associated with the cytoplasmic portions of the CD4 and CD8 surface receptors. Association of the TCR with a peptide antigen-bound MHC complex facilitates the interaction of CD4 and CD8 with MHC class II and class I molecules, respectively, thereby recruiting the associated Lck protein to the vicinity of the TCR/CD3 complex. Lck then phosphorylates tyrosines residues within the immunoreceptor tyrosine-based activation motifs of the cytoplasmic tails of the TCR-γ chains and CD3 subunits, initiating the TCR/CD3 signaling pathway. Lck also contributes to signaling by other receptor molecules. It associates directly with the cytoplasmic tail of CD2, which leads to hyperphosphorylation and activation of Lck, and also plays a role in the IL-2 receptor-linked signaling pathway that controls the T cell proliferative response. Binding of IL-2 to its receptor results in increased activity of Lck. Phosphorylated Tyr-505 associates with the SH2 domain in the amino-terminal half of the protein. | Additional information: Clone REA673 displays negligible binding to Fc receptors. | |
| Immunogen | n/a |
| Other Names | LSK |
| Gene, Accession # | Gene ID: 3932 |
| Catalog # | 130-110-285 |
| Price | $325 |
| Order / More Info | Lck pY505, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Yasuda, K. et al. (2002) Cutting edge: Fyn is essential for tyrosine phosphorylation of Csk-binding protein/phosphoprotein associated with glycolipid-enriched microdomains in lipid rafts in resting T cells. J Immunol 169 (6): 2813-2817. | Rao, N. et al. (2002) Negative regulation of Lck by Cbl ubiquitin ligase. Proc. Natl. Acad. Sci. U.S.A. 99 (6): 3794-3799. | Bergman, M. et al. (1992) The human p50csk tyrosine kinase phosphorylates p56lck at Tyr-505 and down regulates its catalytic activity. EMBO J. 11 (8): 2919-2924. | Salmond, R. J. et al. (2009) T-cell receptor proximal signaling via the Src-family kinases, Lck and Fyn, influences T-cell activation, differentiation, and tolerance. Immunol. Rev. 228 (1): 9-22. | Perlmutter, R. M. et al. (1988) Structure and expression of lck transcripts in human lymphoid cells. J. Cell. Biochem. 38 (2): 117-126. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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