STAT3 pS727, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | STAT3 pS727, Human |
| Clone | REA324 |
| Host Species | Recombinant Human |
| Reactive Species | human |
| Isotype | IgG1 |
| Format | Vio B515 conjugate |
| Size | 100 tests in 1 mL |
| Concentration | 1:11 |
| Applications | Intracellular flow cytometry, MICS (MACSima Imaging Cyclic Staining), Immunofluorescence, Immunohistochemistry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | STAT3 pS727 Antibody, anti-human, Vio® B515, REAfinity™. Clone REA324 recognizes the signal transducer and activator of transcription 3 (STAT3) antigen phosphorylated at serine 727 (pS727). STAT3 expression is found ubiquitously. It is activated in response to various growth factors, hormones, and cytokines, and has an important role in their signaling. When these ligands bind to the specific transmembrane STAT3 receptor, STAT3 becomes activated by tyrosine phosphorylation of two important phosphorylation sites, pY705 and pS727. The dimeric STAT3 translocates to the nucleus, where it binds to consensus STAT3 binding sequences within the promoter region of target genes and thereby activates their transcription. The persistent activation of STAT3 also mediates tumor-promoting inflammation. STAT3 promotes pro-oncogenic inflammatory pathways in tumor inflammation and immunity, including nuclear factor-κB and interleukin-6-GP130-Janus kinase pathways, and by opposing STAT1- and NF-κB-mediated T helper 1 anti-tumor immune responses. | Additional information: Clone REA324 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | ADMIO, APRF, HIES |
| Gene, Accession # | Gene ID: 6774 |
| Catalog # | 130-109-708 |
| Price | $370 |
| Order / More Info | STAT3 pS727, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Zhang, X. et al. (1995) Requirement of serine phosphorylation for formation of STAT-promoter complexes. Science 267 (5206): 1990-1994. | Sakaguchi, M. et al. (2012) Role and regulation of STAT3 phosphorylation at Ser727 in melanocytes and melanoma cells. J. Invest. Dermatol. 132 (7): 1877-1885. | Yu, H. et al. (2009) STATs in cancer inflammation and immunity: a leading role for STAT3. Nat. Rev. Cancer 9 (11): 798-809. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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