CD178, Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | CD178, Mouse |
| Clone | REA1171 |
| Host Species | Recombinant Human |
| Reactive Species | mouse |
| Isotype | IgG1 |
| Format | Vio Bright B515 conjugate |
| Size | 150 µg in 1 mL |
| Concentration | 1:50 |
| Applications | Flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | CD178 Antibody, anti-mouse, Vio® Bright B515, REAfinity™. Clone REA1171 recognizes the type II transmembrane glycoprotein mouse CD178, also known as Fas Ligand, FasL, or CD95 Ligand, which is a 40 kDa member of the TNF cytokine family expressed on activated lymphocytes such as T cells, NK cells, or monocytes as well as in immune-privilaged sites, e.g, cornea or testis. CD178 can trigger apoptosis through trimerization of the Fas receptor CD95. Thereby, CD178 and CD95 play a key role in the regulation of the immune system. Cleavage of membrane bound CD178 from the cell surface via matrix metalloproteinases (such as MMP-7) generates soluble CD178 molecules. | Additional information: Clone REA1171 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | FasL, APT1LG1, CD95L, TNFSF6, gld |
| Gene, Accession # | Gene ID: 14103 |
| Catalog # | 130-120-925 |
| Price | $700 |
| Order / More Info | CD178, Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Takahashi, T. et al. (1994) Generalized lymphoproliferative disease in mice, caused by a point mutation in the Fas ligand. Cell 76 (6): 969-976. | Oyaizu, N. et al. (1997) Monocytes express Fas ligand upon CD4 cross-linking and induce CD4+ T cells apoptosis: a possible mechanism of bystander cell death in HIV infection. J Immunol 158: 2456 -2463. | Kayagaki, N. et al. (1997) Polymorphism of murine Fas ligand that affects the biological activity. Proc. Natl. Acad. Sci. U.S.A. 94: 3914 -3919. | Janssen, O. et al. (2003) CD95 ligand - death factor and costimulatory molecule? Cell Death Differ. 10 (11): 1215-1225. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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