CD357 (GITR), Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | CD357 (GITR), Mouse |
| Clone | REA980 |
| Host Species | Recombinant Human |
| Reactive Species | mouse |
| Isotype | IgG1 |
| Format | phycoerythrin (PE) conjugate |
| Size | 30 µg in 200 µL |
| Concentration | 1:50 |
| Applications | Flow cytometry, MICS (MACSima Imaging Cyclic Staining), Immunofluorescence, Immunohistochemistry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | CD357 (GITR) Antibody, anti-mouse, PE, REAfinity™. Clone REA980 recognizes the mouse CD357 antigen, also known as glucocorticoid-induced TNF-receptor (GITR) or TNFRSF18. CD357 is a member of the TNF receptor superfamily. It is expressed at low levels on resting T lymphocytes and at high levels on CD4+CD25+ regulatory T cells (Tregs). Activation of T cells upregulates CD357 expression. Interaction of CD357 (GTITR) with its ligand (GITRL) has been demonstrated to augment T cell activation, proliferation, cytokine production, as well as MAPKs and NF-κB activation. CD357 plays an important role in the function of CD4+CD25+ Tregs. | Additional information: Clone REA980 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | GITR, TNFRSF18, AITR |
| Gene, Accession # | Gene ID: 21936 |
| Catalog # | 130-116-426 |
| Price | $71 |
| Order / More Info | CD357 (GITR), Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Nocentini, G. et al. (1997) A new member of the tumor necrosis factor/nerve growth factor receptor family inhibits T cell receptor-induced apoptosis. Proc. Natl. Acad. Sci. U.S.A. 94: 6216-6221. | Ronchetti, S. et al. (2002) Role of GITR in activation response of T lymphocytes. Blood 100 (1): 350-352. | Rochetti, S. et al. (2004) GITR, a member of the TNF receptor superfamily, is costimulatory to mouse T lymphocyte subpopulations. Eur. J. Immunol. 34 (3): 613-622. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
Profile of MILTENYI BIOTEC B.V. & Co. KG