CD133/2, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | CD133/2, Human |
| Clone | 293C3 |
| Host Species | Mouse |
| Reactive Species | human |
| Isotype | IgG2bκ |
| Format | Vio Bright FITC conjugate |
| Size | 30 tests in 60 µL |
| Concentration | 1:50 |
| Applications | Flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | CD133/2 Antibody, anti-human, Vio® Bright FITC. CD133 is a novel 5-transmembrane cell surface antigen with a molecular weight of 117 kDa. CD133/2 (293C3) antibodies recognize epitope 2 of the human CD133 antigen (CD133/2). In the hematopoietic system, CD133 expression is restricted to a subset of CD34bright stem and progenitor cells in human fetal liver, bone marrow, cord blood, and peripheral blood. Additionally, CD133 is expressed by a small portion of CD34- cells in these tissues. The CD34+CD133+ cell population, which includes CD34+CD38- cells, was shown to be capable of repopulating NOD/SCID mice. Recently, CD133 has also been found to be expressed on circulating endothelial progenitor cells, tissue-specific stem cells, cancer stem cells from tumor tissues, fetal neural stem cells, and ES and iPS cell-derived cells as well as on other tissue-specific stem cells, such as renal, prostate, and corneal stem cells. The putative murine homologue, prominin, which is expressed on neuroepithelial and epithelial mouse cells, was dentified. |
| Immunogen | n/a |
| Other Names | PROM1, AC133, CORD12, MCDR2, MSTP061, PROML1, RP41, STGD4 |
| Gene, Accession # | Gene ID: 8842 |
| Catalog # | 130-113-750 |
| Price | $209 |
| Order / More Info | CD133/2, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Miraglia, S. et al. (1997) A novel five-transmembrane hematopoietic stem cell antigen: isolation, characterization, and molecular cloning. Blood 90 (12): 5013-5021. | Yin, A. H. et al. (1997) AC133, a novel marker for human hematopoietic stem and progenitor cells. Blood 90: 5002-5012. | Gallacher, L. et al. (2000) Isolation and characterization of human CD34-Lin- and CD34+Lin- hematopoietic stem cells using cell surface markers AC133 and CD7. Blood 95 (ARVO Annual Meeting Abstract): 2813-2820. | Peichev, M. et al. (2000) Expression of VEGFR-2 and AC133 by circulating human CD34+ cells identifies a population of functional endothelial precursors. Blood 95: 952-958. | Uchida, N. et al. (2000) Direct isolation of human central nervous system stem cells. Proc. Natl. Acad. Sci. U.S.A. 97: 14720-14725. | Weigmann, A. et al. (1997) Prominin, a novel microvilli-specific polytopic membrane proteine of the apical surface of epithelial cells, is targeted to plasmalemmal protrusions of non-epithelial cells. Proc. Natl. Acad. Sci. U.S.A. 94: 12425-12430. | Pfenninger, C. V. et al. (2007) CD133 is not present on neurogenic astrocytes in the adult subventricular zone, but on embryonic neural stem cells, ependymal cells, and glioblastoma cells. Cancer Res. 67 (12): 5727-5736. | Bussolati, B. et al. (2005) Isolation of renal progenitor cells from adult human kidney. Am. J. Pathol. 166: 545-555. | Buhring, H. J. et al. (1999) Expression of novel surface antigens on early hematopoietic cells. Ann. N. Y. Acad. Sci. 872: 25-39. | Richardson, G. et al. (2004) CD133, a novel marker for human prostatic epithelial stem cells. J. Cell. Sci. 117: 3539-3545. | Walton, R. M. et al. (2013) Postnatal neural precursor cell regions in the rostral subventricular zone, hippocampal subgranular zone and cerebellum of the dog (Canis lupus familiaris). Histochem. Cell Biol. 139 (3): 415-429. | Thill, M. et al. (2004) Identification of a population of CD133+ precursor cells in the stroma of human cornea. Invest. Ophthalmol. Vis. Sci. 45: 3519. | Buhring, H. J. et al. (1991) The product of the proto-oncogene c-kit (P145c-kit) is a human bone marrow surface antigen of hematopoietic precursor cells which is expressed on a subset of acute non-lymphoblastic cells. Leukemia 5: 854-860. | Kurian, L. et al. (2013) Conversion of human fibroblasts to angioblast-like progenitor cells. Nat. Methods 10 (1): 77-83. | Cox, J. L. et al. (2012) Elevating SOX2 levels deleteriously affects the growth of medulloblastoma and glioblastoma cells. PLoS One 7 (8): e44087. | Donnenberg, A. D. et al. (2013) KIT (CD117) expression in a subset of non-small cell lung carcinoma (NSCLC) patients. PLoS One 7 (12): e52885. | Balasubramanian, P. et al. (2013) AQP9 expression in glioblastoma multiforme tumors is limited to a small population of astrocytic cells and CD15+/CalB+ leukocytes. PLoS One 8 (9): e75764. | de Wynter, E. A. et al. (1998) CD34+AC133+ cells isolated from cord blood are highly enriched in long-term culture-initiating cells, NOD/SCID-repopulating cells and dendritic cell progenitors. Stem Cells 16: 387-396. | Kang, T. W. et al. (2014) Growth arrest and forced differentiation of human primary glioblastoma multiforme by a novel small molecule. Sci Rep 4: 5546. | Hawley, R. G. et al. (2006) Hematopoietic stem cells. Meth. Enzymol. 419: 149-179. | Golden, J. E. et al. (2012) Human umbilical cord blood cells alter blood and spleen cell populations after stroke. Transl Stroke Res 3 (4): 491-499. | Wang, L. et al. (2013) Enrichment of prostate cancer stem-like cells from human prostate cancer cell lines by culture in serum-free medium and chemoradiotherapy. Int. J. Biol. Sci. 9 (5): 472-479. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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