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Antigenic Specificity | CD106 (VCAM-1), Rat |
Clone | MR106 |
Host Species | Mouse |
Reactive Species | rat |
Isotype | IgG1κ |
Format | phycoerythrin (PE) conjugate |
Size | 9 µg in 300 µL |
Concentration | 1:10 |
Applications | Flow cytometry |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | CD106 (VCAM-1) Antibody, anti-rat, PE. Clone MR106 recognizes the CD106 antigen, a 110 kDa transmembrane protein also known as vascular cell adhesion protein 1 (VCAM-1). CD106 is expressed on bone marrow stromal cells, myeloid cells, and dendritic cells, but not on peripheral leukocytes. Expression on endothelial cells is upregulated upon inflammatory cytokine stimulation. CD106 is an endothelial ligand for the very late antigen-4 (VLA-4 or α4β1) of the β1 subfamily of integrins, and for integrin α4β7. It mediates the adhesion of lymphocytes, monocytes, eosinophils, and basophils to vascular endothelium. CD106 also functions in leukocyte-endothelial cell signal transduction, and it may play a role in the development of atherosclerosis and rheumatoid arthritis. |
Immunogen | n/a |
Other Names | VCAM1, VCAM1B |
Gene, Accession # | Gene ID: 25361 |
Catalog # | 130-103-749 |
Price | $43 |
Order / More Info | CD106 (VCAM-1), Rat Antibody from MILTENYI BIOTEC B.V. & Co. KG |
Product Specific References | Hession, C. et al. (1992) Cloning of murine and rat vascular cell adhesion molecule-1. Biochem. Biophys. Res. Commun. 183 (1): 163-169. | Barreiro, O. et al. (2002) Dynamic interaction of VCAM-1 and ICAM-1 with moesin and ezrin in a novel endothelial docking structure for adherent leukocytes. J. Cell Biol. 157 (7): 1233-1245. | Gao, Z. et al. (2012) Vascular endothelial growth factor participates in modulating the C6 glioma-induced migration of rat bone marrow-derived mesenchymal stem cells and upregulates their vascular cell adhesion molecule-1 expression. Exp Ther Med. 4 (6): 993-998. |