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Antigenic Specificity | CD122 (IL-2Rβ), Human |
Clone | REA167 |
Host Species | Recombinant Human |
Reactive Species | human |
Isotype | IgG1 |
Format | allophycocyanin (APC) conjugate |
Size | 30 tests in 300 µL |
Concentration | 1:11 |
Applications | Flow cytometry |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | CD122 (IL-2Rβ) Antibody, anti-human, APC, REAfinity™. Clone REA167 recognizes CD122, the 75 KDa β subunit of the high and intermediate affinity interleukin 2 receptor (IL-2R). CD122 is a type I transmembrane protein, and together with α subunit (CD25) or with α and γ (CD132) subunit, it forms the heteromeric intermediate and high affinity IL-2 receptors, respectively. In addition, CD122 is also a component of the IL-15 receptor complex. Expression of CD122 is found constitutively in CD8 cytotoxic T cells but not in CD4 T? cells and is further induced upon T cell activation. CD16+ NK lymphocytes also express CD122 constitutively. CD122 is essential for IL-2 signaling. | Additional information: Clone REA167 displays negligible binding to Fc receptors. ????? |
Immunogen | n/a |
Other Names | IL2RB, IL-15RB, P70-75 |
Gene, Accession # | Gene ID: 3560 |
Catalog # | 130-100-248 |
Price | $142 |
Order / More Info | CD122 (IL-2Rβ), Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
Product Specific References | Gesbert, F. et al. (2005) IL-2 responsiveness of CD4 and CD8 lymphocytes: further investigations with human IL-2Rβ transgenic mice. Int. Immunol. 17: 1093-1102. | Friedmann, M. C. et al. (1996) Different interleukin 2 receptor beta-chain tyrosines couple to at least two signaling pathways and synergistically mediate interleukin 2-induced proliferation. Proc. Natl. Acad. Sci. U.S.A. 93 (5): 2077-2082. | Migone, T. S. et al. (1998) Functional cooperation of the interleukin-2 receptor beta chain and Jak1 in phosphatidylinositol 3-kinase recruitment and phosphorylation. Mol. Cell. Biol. 18 (11): 6416-6422. |