Ikaros, Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | Ikaros, Mouse |
| Clone | REA919 |
| Host Species | Recombinant Human |
| Reactive Species | mouse |
| Isotype | IgG1 |
| Format | phycoerythrin (PE) conjugate |
| Size | 150 µg in 1 mL |
| Concentration | 1:50 |
| Applications | Intracellular flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Ikaros Antibody, anti-mouse, PE, REAfinity™. Clone REA919 recognizes the mouse Ikaros protein, also known as DNA-binding protein Ikaros, Ikaros family zinc finger protein 1, or IKZF1. Ikaros is a transcription regulator of hematopoietic cell differentiation of lymphocytes, B cells, and T cells, and functions as a major tumor suppressor involved in human B cell acute lymphoblastic leukemia. In association with other Ikaros-family members, e.g. Aiolos and Helios, Ikaros forms heterodimers, that are important for normal progression to a mature and immunocompetent state. Ikaros is found in the nucleus to a higher extent in granulocytes, B cells, T cells, and NK cells, and in lower levels in erythroblasts, megakaryocytes, and monocytes. | Additional information: Clone REA919 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | Ikaros family zinc finger protein 1, Lyf1, Zfpn1a1, Znfn1a1, Ikzf1 |
| Gene, Accession # | Gene ID: 22778 |
| Catalog # | 130-115-274 |
| Price | $240 |
| Order / More Info | Ikaros, Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Morgan, B. et al. (1997) Aiolos, a lymphoid restricted transcription factor that interacts with Ikaros to regulate lymphocyte differentiation. EMBO J. 16 (8): 2004-2013. | Watkins, N. A. et al. (2009) A HaemAtlas: characterizing gene expression in differentiated human blood cells. Blood 113 (19): . | Kastner, P. et al. (2011) Role of Ikaros in T-cell acute lymphoblastic leukemia. J. Biol. Chem. 2 (6): 108-114. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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