CD114, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | CD114, Human |
| Clone | REA1082 |
| Host Species | Recombinant Human |
| Reactive Species | human |
| Isotype | IgG1 |
| Format | allophycocyanin (APC) conjugate |
| Size | 100 tests in 200 µL |
| Concentration | 1:50 |
| Applications | Flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | CD114 Antibody, anti-human, APC, REAfinity™. Clone REA1082 recognizes the receptor for granulocyte colony stimulating factor (G-CSFR, CSF3) a 130-150 kDa type I transmembrane glycoprotein of the class 1 cytokine receptor gene family also known as CD114. Ligand binding leads to homodimerization and subsequent signal transduction involving the JAK-STAT pathway. CD114 is expressed by neutrophils at all stages of differentiation but also found on monocytes, endothelial cells, mature platelets, trophoblasts, and placenta. | Additional information: Clone REA1082 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | CSF-3R, G-CSFR |
| Gene, Accession # | Gene ID: 1441 |
| Catalog # | 130-119-007 |
| Price | $325 |
| Order / More Info | CD114, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Ward, A. C. (2007) The role of the granulocyte colony-stimulating factor receptor (G-CSF-R) in disease. Front Biosci. 12: 608-618. | Liongue, C. et al. (2009) Granulocyte colony-stimulating factor receptor: stimulating granulopoiesis and much more. Int. J. Biochem. Cell Biol. 12 (41): 2372-2375. | Piper, M. G. et al. (2010) Neutrophil elastase downmodulates native GCSFR expression and granulocyte-macrophage colony formation. J. Inflamm. 7 (1): 5. | Gibbs, K. D. et al. (2011) Single-cell phospho-specific flow cytometric analysis demonstrates biochemical and functional heterogeneity in human hematopoietic stem and progenitor compartments. Blood 117: 4226-4233. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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