CD274 (B7-H1), Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | CD274 (B7-H1), Human |
| Clone | REA1197 |
| Host Species | Recombinant Human |
| Reactive Species | human |
| Isotype | IgG1 |
| Format | Vio Bright B515 conjugate |
| Size | 100 tests in 200 µL |
| Concentration | 1:50 |
| Applications | 3D-Immunofluorescence, Immunohistochemistry, Immunofluorescence |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | CD274 (B7-H1) Antibody, anti-human, Vio® Bright B515, REAfinity™. Clone REA1197 recognizes the human CD274 antigen, also known as programmed cell death 1 ligand 1 (PD-L1), an immune inhibitory receptor ligand which is involved in the costimulatory signal, essential for T cell proliferation and production of interleukin 10 (IL-10) and interferon γ (IFN-γ). | CD274 is expressed on activated T cells, B cells, dendritic cells (DCs), antigen-presenting cells, keratinocytes, monocytes, and various types of tumor cells. In tissues, CD274 is highly expressed in the heart, skeletal muscle, placenta, and lung and weakly expressed in the thymus, spleen, kidney, and liver. | PD-L1 is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. | Additional information: Clone REA1197 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | programmed cell death 1 ligand 1, PD-L1, PDCD1L1, PDCD1LG1, PDCD1 ligand 1, B7 homolog 1, B7H1 |
| Gene, Accession # | Gene ID: 29126 |
| Catalog # | 130-122-813 |
| Price | $425 |
| Order / More Info | CD274 (B7-H1), Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Freeman, G. J. et al. (2000) Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation. J. Exp. Med. 192 (7): 1027-1034. | Youngnak, P. et al. (2003) Differential binding properties of B7-H1 and B7-DC to programmed death-1. Biochem. Biophys. Res. Commun. 307 (3): 672-677. | Ahmed, M. et al. (2017) The too many faces of PD-L1: a comprehensive conformational analysis study. Biochemistry 56 (40): 5428-5439. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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