Siglec-5/Siglec-14, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | Siglec-5/Siglec-14, Human |
| Clone | REA393 |
| Host Species | Recombinant Human |
| Reactive Species | human |
| Isotype | IgG1 |
| Format | Vio Bright FITC conjugate |
| Size | 30 tests in 300 µL |
| Concentration | 1:11 |
| Applications | Flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Siglec-5/Siglec-14 Antibody, anti-human, Vio® Bright FITC, REAfinity™. Clone REA393 recognizes the human siglec-5 and siglec-14 antigens, which are both single pass transmembrane protein members of the immunoglobulin superfamily. Siglec-5 is also known as CD170. Siglec-5 has four extracellular Ig-like domains and a cytosolic inhibitory motif. Siglec-14 was discovered with three Ig-like domains and has almost complete sequence identity with siglec-5 at the first two Ig-like domains, shows a glycan binding preference similar to that of siglec-5, and associates with the activating adapter protein DAP12. Siglec-5 is expressed on granulocytes and monocytes as well as on plasmacytoid dendritic cells, monocyte-derived dendritic cells, and macrophages. It is potentially involved in the negative regulation of innate immune responses, and also suggested to be a useful diagnostic and therapeutic marker for acute myelogenous leukemia. Siglec-14 is expressed on granulocytes and B cells. Some individuals lack the expression of siglec-14, while they all express siglec-5. | Additional information: Clone REA393 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | CD170, CD33L2, OB-BP2, OBBP2, SIGLEC5, Siglec14 |
| Gene, Accession # | Gene ID: 8778, 100049587 |
| Catalog # | 130-106-071 |
| Price | $158 |
| Order / More Info | Siglec-5/Siglec-14, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Cornish, A. L. et al. (1998) Characterization of Siglec-5, a novel glycoprotein expressed on myeloid cells related to CD33. Blood 92 (6): 2123-2132. | Ali, S. R. et al. (2014) Siglec-5 and Siglec-14 are polymorphic paired receptors that modulate neutrophil and amnion signaling responses to group B Streptococcus. J. Exp. Med. 211 (6): 1231-1242. | Angata, T. et al. (2006) Discovery of Siglec-14, a novel sialic acid receptor undergoing concerted evolution with Siglec-5 in primates. FASEB J. 20 (12): 1964-1973. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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