BDNF, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | BDNF, Human |
| Clone | REA358 |
| Host Species | Recombinant Human |
| Reactive Species | human |
| Isotype | IgG1 |
| Format | phycoerythrin (PE) conjugate |
| Size | 30 tests in 60 µL |
| Concentration | 1:50 |
| Applications | Intracellular flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | BDNF Antibody, anti-human, PE, REAfinity™. Clone REA358 recognizes the human brain-derived neurotrophic factor (BDNF) antigen, a secreted protein which is a member of the neurotrophin family of growth factors and related to the canonical nerve growth factor. BDNF is highly expressed in hippocampus, amygdala, cerebral cortex, and cerebellum. It is also expressed in heart, lung, skeletal muscle, testis, prostate, and placenta. During development, BDNF promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. It participates in axonal growth, pathfinding, and in the modulation of dendritic growth and morphology. BDNF is a major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation, long-term depression, certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability. Binding of BDNF to its receptor TrkB elicits various intracellular signaling pathways, including MAPK/ERK, PLCg, and PI3K pathways. | Additional information: Clone REA358 displays negligible binding to Fc receptors. | |
| Immunogen | n/a |
| Other Names | ANON2, BULN2 |
| Gene, Accession # | Gene ID: 627 |
| Catalog # | 130-127-995 |
| Price | $139 |
| Order / More Info | BDNF, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Jones, K. R. et al. (1990) Molecular cloning of a human gene that is a member of the nerve growth factor family. Proc. Natl. Acad. Sci. U.S.A. 87 (20): 8060-8064. | Numakawa, T. et al. (2010) BDNF function and intracellular signaling in neurons. Histol. Histopathol. 25 (2): 237-258. | Yoshii, A. et al. (2010) Postsynaptic BDNF-TrkB signaling in synapse maturation, plasticity, and disease. Dev. Neurobiol. 70 (5): 304-322. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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