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Antigenic Specificity | CD64, Human |
Clone | REA978 |
Host Species | Recombinant Human |
Reactive Species | human, nonhuman primate |
Isotype | IgG1 |
Format | PE-Vio 615 conjugate |
Size | 30 tests in 60 µL |
Concentration | 1:50 |
Applications | Flow cytometry |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | CD64 Antibody, anti-human, PE-Vio® 615, REAfinity™. Clone REA978 recognizes the human CD64 antigen, a high affinity Fc receptor for IgG, also known as FcγRI. CD64 contains three Ig-like domains in its extracellular domain and binds both monomeric and aggregated IgG and contributes to antibody-dependent cellular cytotoxicity (ADCC), phagocytosis, and the clearance of immune complexes. It is constitutively expressed on macrophages, monocytes, and eosinophils and can be up-regulated on neutrophils during infection or after stimulation with IFN-γ and colony-stimulating factors G-CSF and GM-CSF. | Additional information: Clone REA978 displays negligible binding to Fc receptors. |
Immunogen | n/a |
Other Names | FCGR1A, CD64A, FcR I, IGFR1, FcγRI |
Gene, Accession # | Gene ID: 2209 |
Catalog # | 130-116-307 |
Price | $142 |
Order / More Info | CD64, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
Product Specific References | Shen, L. et al. (1987) Polymorphonuclear leukocyte function triggered through the high affinity Fc receptor for monomeric IgG. J Immunol 139 (2): 534-538. | Buckle, A. M. and Hogg, N. (1989) The effect of IFN-gamma and colony-stimulating factors on the expression of neutrophil cell membrane receptors. J Immunol 143 (7): 2295-2301. | Herra, C. et al. (1996) Increased expression of Fc gamma receptors on neutrophils and monocytes may reflect ongoing bacterial infection. J. Med. Microbiol. 44 (2): 135-140. |