Under-phospho Rb, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | Under-phospho Rb, Human |
| Clone | REA708 |
| Host Species | Recombinant Human |
| Reactive Species | human |
| Isotype | IgG1 |
| Format | fluorescein (FITC) conjugate |
| Size | 100 tests in 200 µL |
| Concentration | 1:50 |
| Applications | Intracellular flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Under-phospho Rb Antibody, anti-human, FITC, REAfinity™. Clone REA708 recognizes the human Under-phospho Rb, also known as underphosphorylated Rb protein (retinoblastoma protein). The retinoblastoma protein is a nuclear phosphoprotein which acts as a tumor suppressor in normal cells. The underphosphorylated, active form of the retinoblastoma protein is present in resting or completely differentiated cells and can interact with E2F1 and represses its transcription activity, which leads to cell cycle arrest. The phosphorylated forms of retinoblastoma protein are found in proliferating cells. | Additional information: Clone REA708 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | Underphosphorylated retinoblastoma protein, Retinoblastoma-associated protein, p105-Rb, pRb, RB, pp110, Underphosphorylated RB |
| Gene, Accession # | Gene ID: 5925 |
| Catalog # | 130-110-546 |
| Price | $264 |
| Order / More Info | Under-phospho Rb, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Chellappan, S. et al. (1992) Adenovirus E1A, simian virus 40 tumor antigen, and human papillomavirus E7 protein share the capacity to disrupt the interaction between transcription factor E2F and the retinoblastoma gene product. Proc. Natl. Acad. Sci. U.S.A. 89 (10): 4549-4553. | Harbour, J. W. et al. (2000) Rb function in cell-cycle regulation and apoptosis. Nat. Cell Biol. 2 (4): 65-67. | Ren, S. et al. (2004) Cyclin C/cdk3 promotes Rb-dependent G0 exit. Cell 117 (2): 239-251. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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